Building discontinuous liver sinusoidal vessels

V体育官网 - The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature

Peghaire1, Dufton2, Lang3 et al. 2019Nat Commun425410Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Specifically, the liver synthesizes and releases most of the proteins involved in the clotting cascade (such as fibrinogen, protein C and protein S) 51 . This high local concentration of coagulation factors and the unique architecture of liver sinusoids, presenting fenestrated and discontinuous EC 52 , might explain why the most pronounced phenotype in Erg iEC-KO mice is observed in this tissue. Moreover, one of ERG’s key function is to promote vascular stability though the transcriptional control of genes, such as VE-cadherin and claudin-5 27 VSports app下载. …”Section: Discussionmentioningconfidence: 99%

V体育安卓版 - The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature

Peghaire1, Dufton2, Lang3 et al. 2019Nat Commun425410Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Объектом исследования нашей работы служили собаки. При выборе объекта исследования мы руководствовались тем, что анатомия, физиология и морфологическое строение печени собаки и человека наиболее близки [17,23,24]. Строение и функции пищеварительного тракта, основные источники кровообращения и пути оттока крови, строение артериального и венозного русла, а следовательно, и гемоциркуляторного русла органов желудочнокишечного тракта у собаки и человека сходны [17]. …”Section: материал и методы исследованияunclassified“…Другими словами, патологический процесс начинается и заканчивается на гемоциркуляторном уровне. По мнению большинства исследователей, метаболические расстройства являются следствием нарушений гемодинамики, они нередко вызываются и затем поддерживаются тканевой гипоксией [1-3, 20, 23,24]. …”Section: Introductionunclassified“…Основную функцию гемоциркуляторной системы в печени -транскапиллярный обмен -осуществляет эндотелий синусоидов, на клеточном уровне снабжая клетки питательными веществами, кислородом и удаляя продукты обмена [16,18,19,23,28]. Стенки синусоидов в норме не имеют базальной мембраны и образованы плоскими эндотелиальными клетками с большими межклеточными промежутками, что облегчает перенос белковосвязанных веществ из синусоидов сначала в пространство Диссe, расположенное между эндотелиальными клетками и гепатоцитами, а затем и в сами гепатоциты, а также ускоряет экскрецию липопротеинов и других веществ из гепатоцитов в синусоиды [8,18,23,24,26,27]. Кровь из синусоидов поступает в центральную дольковую вену, а затем в собирательные и печеночные вены, которые впадают в нижнюю полую вену [2,3,18]. …”Section: IntroductionunclassifiedSee 1 more Smart Citation

"VSports" Morphofunctional changes of the hemocirculatory bed of the liver in different types of acute small bowel obstruction

Milyukov1, Моталов2, Sharifova3 2018Regional blood circulation and microcirculation0000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…With high exposure to circulating endotoxins and antigens from the gut, the liver also plays a central role in the immunological response to remove toxic agents from the bloodstream [1]. These functions are supported by the presence of discontinuous sinusoids formed by fenestrated endothelium with intercellular gaps and fragmented basement membrane to facilitate the bidirectional transport of cells and molecules across the sinusoidal barrier [2]. Lining the endothelium, liver sinusoidal endothelial cells (LSECs) are highly specialised cells that constitute the permeable barrier between the blood and liver parenchyma [3]. …”Section: Introductionmentioningconfidence: 99%

Titanium Dioxide Nanoparticles Enhance Leakiness and Drug Permeability in Primary Human Hepatic Sinusoidal Endothelial Cells

Tee1, Ng2, Koh3 et al. 2018IJMS290270Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.