NAD ⁺ repletion improves muscle function in muscular dystrophy and counters global PARylation

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Rajman1, Chwalek2, Sinclair3 2018Cell Metabolism77097000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…NR also increases the number and quality of muscle stem cells (MuSC) and enhances muscle regeneration in old mice, in part, by improving mitochondrial function and preventing MuSC senescence (Zhang et al, 2016). In the context of muscular dystrophy models, NR improves mobility in dystrophic C. elegans mutants (Ryu et al, 2016), NAD + supplementation of zebrafish reduces the percentage of detached muscle fibers and increases mobility (Goody et al, 2012), and in the MDX mouse, NR improves mitochondrial function, recovery from muscle injury, and running capacity (Ryu et al, 2016). …”Section: Effects Of Nad+ Boosters On Physiology and Health In Mouse Mmentioningconfidence: 99%

"VSports" Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Rajman1, Chwalek2, Sinclair3 2018Cell Metabolism77097000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Moreover, MuSCs exhibit an increased ability to differentiate in vitro and to express the differentiation markers myogenin and myosin heavy chain, indicative of their good regenerative potential (298). Finally, mdx mice supplemented for 10 weeks with nicotinamide riboside exhibit an increased number of MuSCs while muscle regeneration is improved, indicating that nicotinamide riboside also prevents MuSC senescence in muscular dystrophy (287,361), as it does in aging muscle (see Section X-B-2: In aging) (Fig. 14). …”Section: A Exercise As Therapymentioningconfidence: 99%“…Inversely, after an acute injury, inducing a compartment-specific increase of the NAD + /NADH ratio (using LbNOX water-forming NOX from Lactobacillus brevis) allowed to decipher the NAD + /NADH ratio-driven signaling and to improve proliferative and metabolic defects in mitochondrial-deficient cells (323). Several studies recently confirmed that the redox couple NAD + /NADH is a privileged target to improve cell and tissue homeostasis, including in aged and diseased skeletal muscle (see Section X. B) (110,287,361). …”Section: Perspectivesmentioningconfidence: 99%

Redox Control of Skeletal Muscle Regeneration

Moal1, Pialoux2, Juban3 et al. 2017Antioxidants & Redox Signaling17821460Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD VSports app下载. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Interestingly, other groups have found a similar inhibitory effect of NAD + repletion by NR supplementation on hepatosteatosis, hepatic inflammation and NLRP3 inflammasome activation in mice [76, 116, 117]. Whether NR could function to suppress the NLRP3 inflammasome has the potential to be explored as a therapeutic agent, given its myriad of other beneficial effects in vivo [118–121]. Accordingly, NAD + repletion by other compounds such as nicotinamide mononucleotide (NMN) similarly ameliorated age-associated adipose tissue inflammation [122], HFD-induced liver inflammation [37] and fructose-rich diet-induced pancreatic islet β cell IL-1β secretion and dysfunction in mice [123]. …”Section: Strategies and Therapeutics To Inhibit The Nlrp3 Inflammasomementioningconfidence: 98%“…Accordingly, NAD + repletion by other compounds such as nicotinamide mononucleotide (NMN) similarly ameliorated age-associated adipose tissue inflammation [122], HFD-induced liver inflammation [37] and fructose-rich diet-induced pancreatic islet β cell IL-1β secretion and dysfunction in mice [123]. These effects of NR and NMN appear to be largely mediated by SIRT1 and/ or SIRT3 [117, 121, 124]. Not surprisingly, resveratrol, the polyphenol present in the skin of grapes, another sirtuin activator, also inhibits NLRP3 inflammasome activation in mice by preserving mitochondrial function, and protects against hepatosteatosis, renal inflammation and LPS-induced lung injury [125–127]. …”Section: Strategies and Therapeutics To Inhibit The Nlrp3 Inflammasomementioningconfidence: 99%

The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome (V体育平台登录)

Traba1, Sack2 2016Cell. Mol. Life Sci. 350280Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.