Efficacy and tolerability of levetiracetam for pediatric refractory epilepsy

V体育安卓版 - Sporadic and Periodic Interictal Discharges in Critically Ill Children: Seizure Associations and Time to Seizure Identification

Sansevere1, DiBacco2, Zhang3 et al. 2021Journal of Clinical Neurophysiology102330Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The side effect profile of several antiseizure medications used to treat status epilepticus (i. e. , levetiracetam, lacosamide) are mild, suggesting that randomized controlled trials examining the impact of prophylactic treatment of IEDs on the development of seizures, high degrees of seizure burden, and neurodevelopmental outcome are safe and feasible. [28][29][30][31][32][33]…”Section: Discussionmentioningconfidence: 99%

Sporadic and Periodic Interictal Discharges in Critically Ill Children: Seizure Associations and Time to Seizure Identification

Sansevere1, DiBacco2, Zhang3 et al. 2021Journal of Clinical Neurophysiology102330Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…However, some ASDs may worsen cognitive problems; certain drugs such as topiramate and valproic acid, especially in polytherapy, have been associated with cognitive and behavioral adverse effects [10]. Given its favorable pharmacokinetic profile [11,12] and good tolerability and safety [13][14][15][16][17], levetiracetam (LEV) was considered a viable alternative in monotherapy in pediatric patients with epilepsy [18]. …”Section: Introductionmentioningconfidence: 99%“…This drug acts through a peculiar mechanism of action -in comparison with the other ASDs-as it binds to the SV2A synaptic vesicle protein, regulating the mechanisms of exocytosis necessary for neurotransmitter release [19]. Levetiracetam showed good broadspectrum antiepileptic efficacy in both focal and generalized epilepsy [15,16], with modest adverse effects. Among the main undesirable effects are drowsiness, asthenia, dizziness, irritability, nervousness, and aggression [20,21]; behavioral effects appear to occur more frequently in younger patients (under 4 years of age). …”Section: Introductionmentioningconfidence: 99%

Cognitive profile in BECTS treated with levetiracetam: A 2-year follow-up

Operto1, Pastorino2, Mazza3 et al. 2019Epilepsy & Behavior303241Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…LEV is a modern AED with broadspectrum efficacy against focal and generalized epilepsy and relatively few pharmacokinetic interactions with other AEDs [1][2][3]. The reported efficacy of LEV in terms of responder rate is between 37% and 100% [9,10,16]. According to these reports, treatment for idiopathic epilepsy was more effective than for epilepsy with an etiologic factor, and monotherapy was more effective than adjunctive therapy. …”Section: Discussionmentioningconfidence: 99%

Efficacy of levetiracetam in epilepsy and effect of concomitant drugs on the incidence of somnolence as an adverse effect

Shimomura1, Minagawa2, Mine3 et al. 2021E&S0000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.