Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action

VSports app下载. Actually, we have already found similar results in previous studies [28][29][30]. 2. 5 Complex 1a and 1b induced apoptotic cell deathSince complexes 1a and 1b showed better cytotoxicity, they were selected to carry out the apoptotic study against HepG-2 cells by Annexin V-FITC/PI assay. …”supportingconfidence: 70%

Improving the anticancer activity of platinum(V体育2025版 - iv) prodrugs using a dual-targeting strategy with a dichloroacetate axial ligand

Liu1, Dong2, Shi3 et al. 2019RSC Adv. 150130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In fact, many other factors also affect the cytotoxic activity of platinum complexes, such as the effective amounts of the compounds that nally act on DNA. Actually, we have already found similar results in previous studies [28][29][30]. 2. 5 Complex 1a and 1b induced apoptotic cell deathSince complexes 1a and 1b showed better cytotoxicity, they were selected to carry out the apoptotic study against HepG-2 cells by Annexin V-FITC/PI assay. …”supportingconfidence: 70%

Improving the anticancer activity of platinum(iv) prodrugs using a dual-targeting strategy with a dichloroacetate axial ligand

Liu1, Dong2, Shi3 et al. 2019RSC Adv. 150130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Attempts were made to conjugate OH‐bearing bioactive molecules to Pt IV . Since no effective protocols exist for the direct conjugation of OH bearing molecules to the axial positions of Pt IV , ester or ether linkers were used to conjugate estrogens, combretastatin‐A4, 7‐hydroxy coumarin, wagonin, or NBDHEX, amongst others, to Pt IV (Figure ). Due to the relative stabilities of the ether and ester bonds, the active moieties are not released rapidly following reduction. …”Section: Figurementioningconfidence: 99%

Expanding the Arsenal of Pt^IV Anticancer Agents: Multi‐action Pt^IV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group

Yempala1, Babu2, Karmakar3 et al. 2019Angew Chem Int Ed652850Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Attempts were made to conjugate OH‐bearing bioactive molecules to Pt IV . Since no effective protocols exist for the direct conjugation of OH bearing molecules to the axial positions of Pt IV , ester or ether linkers were used to conjugate estrogens, combretastatin‐A4, 7‐hydroxy coumarin, wagonin, or NBDHEX, amongst others, to Pt IV (Figure ). Due to the relative stabilities of the ether and ester bonds, the active moieties are not released rapidly following reduction. …”Section: Figurementioningconfidence: 99%

Expanding the Arsenal of Pt^IV Anticancer Agents: Multi‐action Pt^IV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group

Yempala1, Babu2, Karmakar3 et al. 2019Angewandte Chemie111230Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.