CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Undercover: gene control by metabolites and metabolic enzymes

Knaap1, Verrijzer2 2016Genes Dev. 20631640Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The metabolisms of these mice are substantially different from wild-type animals: They are lighter (despite increased food intake), consume more oxygen (suggesting increased energy expenditure), have a higher mitochondrial content, and are protected against diet-induced diabetes and obesity. Similar protective effects on diet-induced diseases have been observed in SIRT1-overexpressing mice (Herranz and Serrano 2010) and CD38 −/− mice (Barbosa et al 2007;Camacho-Pereira et al 2016). The CD38 −/− mice also show increased NAD + levels and up-regulated mitochondrial SIRT3 activity. …”Section: Sirtuins and Parps As Nad + Sensorssupportingconfidence: 60%“…The circadian clock influences expression of NAMPT and, consequently, NAD + levels (Nakahata et al 2009;Ramsey et al 2009;Berger and Sassone-Corsi 2015). Intriguingly, several studies reported that NAD + levels decline during aging (Yoshino et al 2011, Massudi et al 2012, Gomes et al 2013Mouchiroud et al 2013;Camacho-Pereira et al 2016). Possible explanations include accumulated DNA damage leading to increased NAD + consumption by PARP1, up-regulation of NAD + consumer CD38, or reduced levels of NAMPT. …”Section: Diet Nadmentioningconfidence: 99%

Undercover: gene control by metabolites and metabolic enzymes

Knaap1, Verrijzer2 2016Genes Dev. 20631640Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task VSports app下载. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…SIRT3 is also regulated by levels of NAD. Interestingly, the decrease in SIRT3 activity has been associated at least in part with increased expression of the NADase CD38, the expression of which increases with age 207 . Boosting NAD levels has been shown to be an effective approach to protect against bleomycin-induced lung fibrosis, so novel CD38 inhibitors such as thiazoloquin(az)olin(on)es could be beneficial against lung fibrosis 208,209 . …”Section: Targets and Therapeutic Interventions For Mitochondrial Damagementioningconfidence: 99%

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

Mora1, Rojas2, Pardo3 et al. 2017Nat Rev Drug Discov370224801Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…To determine the mechanism and signaling pathways accounting for the induction of NAD + /NADH levels and SIRT3 by RGS14 deficiency, we investigated the CD38 level in skeletal muscle, which is the primary NADase in mammals and regulates cellular levels of NAD (Aksoy, White, Thompson & Chini, 2006; Camacho‐Pereira et al. , 2016; Young, Choleris, Lund & Kirkland, 2006). Decreased CD38 level in RGS14 KO (Figure 3b) was found ( n  = 6–7/group), supporting the increased NAD + level in Figure 3a. …”Section: Resultsmentioningconfidence: 99%

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14

Vatner1, Zhang2, Oydanich3 et al. 2018Aging Cell476560Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.