"V体育2025版" Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer

MARCKS contributes to stromal cancer-associated fibroblast activation and facilitates ovarian cancer metastasis

Yang1, Xu2, Jin3 et al. 2016Oncotarget373370Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task VSports. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Currently, the most definitive molecular marker of CAFs is αSMA, which indicates activation of normal fibroblasts and plays a critical role in mediating communication between the stromal cells and the matrix [26, 31]. Here, we identified a cluster of 503 genes (Supplementary Table S1) that were notably positively correlated with αSMA expression in dataset GSE40595 that includes microdissected ovarian profiling data, of which fibroblasts were shown to be the major constituent [32]. By analyzing overlapping genes with the calculated 784 genes (Supplementary Table S2) in ovarian tumor stroma and 468 genes (Supplementary Table S3) in breast tumor stroma that significantly upregulated compared with their normal fibroblast counterparts in GSE40595 and breast stromal profile GSE9014, we identified ARID4B, COL3A1 and MARCKS as candidate targets for controlling stromal activation (Figure 1A). …”Section: Resultsmentioningconfidence: 99%

"VSports最新版本" MARCKS contributes to stromal cancer-associated fibroblast activation and facilitates ovarian cancer metastasis

Yang1, Xu2, Jin3 et al. 2016Oncotarget373370Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…An anti-CTGF-neutralizing antibody (FG-3019) is capable of specifically binding to CTGF with reasonable affinity and can exhibit an inhibitory effect (3). An anti-CTGF-neutralizing antibody has been demonstrated to be effective in animal models of several malignant diseases, such as pancreatic cancer, ovarian cancer, leukemia, and melanoma, and a phase II clinical trial is currently being conducted in patients with pancreatic cancer (3,6,(41)(42)(43)(44)(45). The effectiveness of an anti-CTGF-neutralizing antibody on HCC was previously unknown. …”Section: Discussionmentioningconfidence: 99%

CTGF Mediates Tumor–Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression

Makino1, Hikita2, Kodama3 et al. 2018Cancer Research1057900Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Western blot analysis by McBroom JW demonstrated increased EPOR expression in multiple ovarian cancer cell lines 42 . CTGF was reported to be a target therapeutic gene in high-grade ovarian cancer 43 . FOS has also been reported as a molecular predictor of progression and survival in ovarian cancer 44 . …”Section: Discussionmentioningconfidence: 99%

The Prognostic 97 Chemoresponse Gene Signature in Ovarian Cancer

Matondo1, Jo2, Shahid3 et al. 2017Sci Rep311370Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.