Fructose-1,6-bisphosphatase opposes renal carcinoma progression

Association between FBP1 and hypoxia-related gene expression in clear cell renal cell carcinoma

Ning1, Teng2, Gong3 et al. 2016Oncology Letters221190Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Low expression of FBP1 has previously been observed in human hepatocellular carcinoma (HC), colon cancer (CC), breast cancer (BC), gastric cancer (GC) and ccRCC tissues (6,(9)(10)(11). The current data is consistent with the latter study. …”Section: Discussionsupportingconfidence: 82%“…Correlation between FBP1 expression and clinicopathological factors in clear cell renal cell carcinoma tissues. Recently, an association between FBP1 expression and various pathological variables in patients with ccRCC was demonstrated at the transcription level (6). By contrast, the current results did not identify a significant association between FBP1 protein expression level and T stage (P=0. 75) or Fuhrman grade (P=0. 36) in ccRCC. …”Section: Fbp1 Expression N (%) -------------------------------------contrastingconfidence: 55%“…Recently, ubiquitous loss of FBP1 expression and its catalytic activity-independent function in ccRCC tissues has been identified, indicating that FBP1 may act as a repressor of HIF in the nucleus by binding to the HIF inhibitory domain (6). However, the association between FBP1 expression status and hypoxia-related gene expression has not been well investigated. …”Section: Introductionmentioningconfidence: 97%See 1 more Smart Citation

Association between FBP1 and hypoxia-related gene expression in clear cell renal cell carcinoma

Ning1, Teng2, Gong3 et al. 2016Oncology Letters221190Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Yet, treating liver cancers with dexamethasone, which is a synthetic and active glucocorticoid, led to the re-activation of gluconeogenesis and increased therapeutic efficacy [202]. Recently, it was also shown that the re-expression of the gluconeogenic enzyme fructose 1,6 bisphosphatase 1 in renal cell carcinoma antagonized its glycolytic phenotype [203]. Examples for novel drug targets, which are in pre-clinical and clinical trials and follow the concept of normalization are inhibitors of the mutant form of isocitrate dehydrogenase. …”Section: Therapeutic Opportunities Of Cancer Metabolismmentioningconfidence: 99%

"V体育平台登录" Organ-Specific Cancer Metabolism and Its Potential for Therapy

Elia1, Schmieder2, Christen3 et al. 2015Handbook of Experimental Pharmacology11601121Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…These results indicate that inhibition of glutaminolysis impedes MYC-induced RCC. Hence, in this transgenic model, MYC appears to be generally programming glutamine metabolism and relying less on glucose metabolism (38,39). …”Section: Inhibition Of Glutaminase By Bptes Slowed Rcc Tumor Progressmentioningconfidence: 99%

VSports app下载 - MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism

Shroff1, Eberlin2, Dang3 et al. 2015Proc. Natl. Acad. Sci. U. S. A. 24182421Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1 VSports app下载. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.