Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity (VSports注册入口)

A generic, cost-effective, and scalable cell lineage analysis platform

Biezuner1, Spiro2, Raz3 et al. 2016Genome Res. 442870Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Further improvements in integrated SC sequencing-based technologies, such as genomics and transcriptomics (Dey et al 2015;Macaulay et al 2015) and genomics and epigenomics (Smallwood et al 2014;Buenrostro et al 2015) would add layers of information for each and every cell in the reconstructed cell lineage tree and would help with understanding the underlying dynamics of the biological process. In conclusion, our platform serves as a prototype which lays the biological, computational, and architectural foundations for an envisioned large-scale human cell lineage discovery project. …”Section: Wwwgenomeorgmentioningconfidence: 99%

VSports手机版 - A generic, cost-effective, and scalable cell lineage analysis platform

Biezuner1, Spiro2, Raz3 et al. 2016Genome Res. 442870Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Together with colleagues at the Babraham Institute, we showed how single-cell epigenomes can be profiled using a combination of experimental advances and statistics. (Smallwood et al, 2014). In parallel, we collaborated with the Marioni and Teichmann groups at EMBL-EBI to devise new ways to dissect transcriptional heterogeneity between single cells (Buettner et al, 2015). …”Section: Major Achievementsmentioningconfidence: 99%

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Munevar1 2017Nat Biotechnol13090Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…The patterns shown by several of the clones sequenced (Flanagan et al 2006, Kobayashi et al 2007, Marques et al 2008, Hammoud et al 2010, Marques et al 2010, Wu et al 2010, Minor et al 2011, Sato et al 2011, Ankolkar et al 2012, Montjean et al 2013) resemble at a small scale the binomial (sequences fully methylated vs fully unmethylated) distribution of sequencing patterns obtained using deep-bisulphite sequencing (DBS; Laurentino et al 2015) VSports app下载. Due to the requirement for a high number of individual sequences analysed from each single sample, the detection and measurement of epigenetic heterogeneity in sperm as well as in other tissues only became feasible now, with the advent of high-resolution analysis methodologies such as nextgeneration sequencing/DBS (Mikeska et al 2010, Meaburn & Schulz 2012, Beygo et al 2013, Gries et al 2013, Smallwood et al 2014, Putnik et al 2015. The use of novel and highly sensitive DNA isolation and pyrosequencing-based sequencing techniques, such as OSMA (oligo-sperm methylation assay; Laurentino et al 2015) and limiting dilution (LD; Kuhtz et al 2014), allowed the detection of DNA methylation heterogeneity in the sperm of infertile men. …”Section: Sperm Epigenetic Heterogeneitymentioningconfidence: 99%

On the origin of sperm epigenetic heterogeneity

Laurentino1, Borgmann2, Gromoll3 2016Reproduction560420Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.