Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia

Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis

Brahma1, Adam2, Pollak3 et al. 2014Journal of Lipid ResearchSelf Cite693401Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…In accordance with the established role of FGF21 as a PPAR ␣ -regulated gene ( 1, 3 ), Jha and colleagues ( 19 ) very recently showed a strong reduction in FGF21 mRNA expression in the liver of ATGL-ko mice accompanied by a substantial decrease in circulating FGF21 levels. Here we show that FGF21 mRNA expression is strongly increased (by 11-fold) in CM of ATGL-ko mice ( Fig. …”Section: Er Stress In CM Of Atgl-defi Cient Mice and Induction Of Er supportingconfidence: 63%“…FGF21 mRNA levels dropped upon PPAR ␣ agonist administration, which has been shown to counteract cardiac study shows that FGF21 mRNA expression is substantially reduced in the liver of ATGL-ko mice, which was paralleled by markedly reduced circulating FGF21 levels ( 19 ). The established role of FGF21 as PPAR ␣ -regulated gene in the liver ( 1,3 ), together with the marked defect in PPAR ␣ -target gene expression in the liver of ATGL-ko mice ( 16 ) or in mice with hepatic ATGL knockdown ( 17 ), strongly suggests that the decline in hepatic FGF21 mRNA of these mouse models is primarily a PPAR ␣ defect. …”Section: Discussionmentioningconfidence: 93%“…TG concentrations defective TG catabolism in ATGL-defi cient mice provokes severe cardiac steatosis and increased hepatic TG levels due to a defect in PPAR ␣ -activated gene expression and FAO in the heart and liver, respectively ( 16,17 ). In accordance with this defect, hepatic FGF21 mRNA expression levels are drastically reduced in ATGL-defi cient mice, leading to a marked drop in circulating FGF21 protein levels ( 19 ). Here we show that FGF21 mRNA expression is substantially increased in cardiac muscle (CM) of mice globally lacking ATGL or specifi cally lacking the ATGL coactivator comparative gene identifi cation-58 (CGI-58) in muscle despite reduced mRNA expression of established PPAR ␣ -regulated and coregulated genes. …”Section: Tissue Tg Measurementmentioningconfidence: 99%“…1A ) despite impaired expression of established PPAR ␣ -regulated genes ( 16 ). The induction of FGF21 expression in CM of ATGL-ko mice could be an adaptation to the strong reduction in hepatic FGF21 mRNA expression and consequently to the decreased circulating FGF21 levels ( 19 ). To address this hypothesis, we measured FGF21 mRNA expression in mice expressing ATGL exclusively in CM on an otherwise ATGL-defi cient background (ATGL-koTgA). …”Section: Er Stress In CM Of Atgl-defi Cient Mice and Induction Of Er mentioningconfidence: 99%See 2 more Smart Citations

Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis (V体育官网)

Brahma1, Adam2, Pollak3 et al. 2014Journal of Lipid ResearchSelf Cite693401Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. “…Hepatoprotective effects of PPARa agonism can also occur via the regulation of hepatic Vnn1 expression [121], since Vnn1-deficiency links hepatic steatosis in response to fasting and changes the expression of inflammation and oxidative stress genes [122]. The role of ATGLdependent intracellular TG hydrolysis, to generate endogenous PPARa agonists with anti-inflammatory potential, was recently demonstrated in Atgl-deficient mice [123], which display increased susceptibility to LPS-and MCDD-induced hepatic inflammation due to impaired PPARa signaling. The hepatic phenotype of Atlg-deficient mice is partially improved upon treatment with a synthetic PPARa agonist. …”Section: Ppara Action In Pre-clinical Models Of Nafldmentioningconfidence: 97%

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

Pawlak1, Lefèbvre2, Staels3 2015Journal of Hepatology1,402459941Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

The Patatin‐Like Phospholipase Domain Containing Protein 7 Facilitates VLDL Secretion by Modulating ApoE Stability

Wang1, Guo2, Wang3 et al. 2020Hepatology311260Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.