Biochanin A Promotes Osteogenic but Inhibits Adipogenic Differentiation: Evidence with Primary Adipose-Derived Stem Cells

Necroinflammation emerges as a key regulator of hematopoiesis in health and disease

Jost1, Höckendorf2 2018Cell Death Differ151130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…These data stand in contrast to a study showing a 10-fold lower IL-1 expression in AML patients compared with healthy controls [130]. The different AML subtypes studied in these two publications might be partially responsible for the contradictory results: high IL-1 expression was found in FAB M4-M5 AML, whereas FAB M0-M2 AML showed low IL-1 expression [115,129,130]. Furthermore, CD34 + and CD38 -AML progenitor cells downregulated the expression of IL-1β by epigenetic silencing, when compared with less primitive AML progenitor cell populations (CD34 + CD38 + ) and even when compared with healthy CD34 + progenitors. …”Section: Necroinflammation and Il-1 In Hematopoietic Malignanciescontrastingconfidence: 99%“…This activation step further promoted the release of cytokines, chemokines, and growth factors [115] VSports app下载. These data stand in contrast to a study showing a 10-fold lower IL-1 expression in AML patients compared with healthy controls [130]. The different AML subtypes studied in these two publications might be partially responsible for the contradictory results: high IL-1 expression was found in FAB M4-M5 AML, whereas FAB M0-M2 AML showed low IL-1 expression [115,129,130]. …”Section: Necroinflammation and Il-1 In Hematopoietic Malignanciescontrastingconfidence: 79%

Necroinflammation emerges as a key regulator of hematopoiesis in health and disease

Jost1, Höckendorf2 2018Cell Death Differ151130Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…There is data confirming positive effects of different polyphenols on the mineralization process [31]. Studies performed on rat primary adipose-derived stem cells (ADSCs) showed that biochanin A increased cellular mineralization and ALP activity, as well as stimulated the expression of the ALP, osteocalcin, Runx2, and OPG [33]. Further studies performed with the ovariectomized rat model of osteoporosis confirmed its osteoblastic activities through an increase of mRNA expression levels of osterix, collagen type I, alkaline phosphatase, and osteocalcin, which were followed by decreased RANKL/OPG ratio [9]. …”Section: Effect Of Isoflavones On Saos-2 Viability and Mineralizationmentioningconfidence: 89%

Evaluation of Isoflavones as Bone Resorption Inhibitors upon Interactions with Receptor Activator of Nuclear Factor-κB Ligand (RANKL)

Zakłos‐Szyda1, Budryn2, Grzelczyk3 et al. 2020Molecules371260Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Among the various sources of MSCs, adipose‐derived stem cells (ADSCs) are abundant and easily obtained from subcutaneous adipose tissue via liposuction in the clinic . ADSCs have been shown to possess multi‐lineage potential, capable of differentiating into adipogenic, osteogenic, myogenic, and chondrogenic cells , and ADSC‐based transplantation is a promising therapeutic approach for tissue regeneration and repair. Understanding the molecular mechanisms involved in ADSC proliferation and differentiation is therefore of paramount importance. …”Section: Introductionmentioningconfidence: 99%

"VSports" The Antiaging Gene Klotho Regulates Proliferation and Differentiation of Adipose-Derived Stem Cells

Fan1, Sun2 2016Stem Cells562450Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.