Identification of Diverse Lipid Droplet Targeting Motifs in the PNPLA Family of Triglyceride Lipases

Sixteen novel mutations in PNPLA1 in patients with autosomal recessive congenital ichthyosis reveal the importance of an extended patatin domain in PNPLA1 that is essential for proper human skin barrier function

Zimmer1, Kim2, Hotz3 et al. 2017Br J Dermatol3043002Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD VSports app下载. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The only mutation outside of the extended patatin domain (Ser382Alafs*74) affects most likely the proline‐rich domain (amino acids 335–417). This domain and similar sequences of other PNPLA family members have been shown to be involved in intracellular targeting, in association with lipid droplets . Therefore, this frameshift mutation might affect the cellular localization and thereby the proper function of PNPLA1 if NMD has not efficiently downregulated its expression. …”Section: Discussionmentioningconfidence: 99%

Sixteen novel mutations in PNPLA1 in patients with autosomal recessive congenital ichthyosis reveal the importance of an extended patatin domain in PNPLA1 that is essential for proper human skin barrier function

Zimmer1, Kim2, Hotz3 et al. 2017Br J Dermatol3043002Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…PNPLA2 (ATGL, adipose triglyceride lipase, also known under the name Desnutrin) is the best-studied TG-converting lipase responsible for most of TG hydrolysis in murine white adipose tissue [27], PNPLA3, also known as Adiponutrin can act as an acyltransferase [28] or a lipase [17] but its biosynthetic acyltransferase activity is being the presumed dominant function [28]. We excluded PNPLA4 from further studies since PNPLA4 lacks C-terminal residues found in all other family members and does not localize to LDs [29]. PNPLA5 possess a lipase activity against TGs [17] but PNPLA5 shows some differences in its active site vs. PNPLA2 and 3, suggesting further sub-specialization. …”Section: Resultsmentioningconfidence: 99%“…bafilomycin A1-inhibitable component) of proteolysis (Figure 7F). Furthermore, overexpression of a mutant PNPLA5 with altered PNLAP5 LD-targeting motif (RSRRLV) [29] decreased proteolysis of long-lived proteins in response to starvation (Figure 7G,H). This effect on proteolysis was mirrored in a similar experiment carried out with overexpression of a CPT1 catalytic site mutant (CPT1Gly 128 Ala) [34] (Figure 7I,J). …”Section: Resultsmentioningconfidence: 99%

Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis

Dupont1, Chauhan2, Arko‐Mensah3 et al. 2014Current Biology240152210Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…They then migrate to droplets upon induction (Jacquier et al, 2011;Thiel et al, 2013;Wilfling et al, 2013). Two motives for droplet targeting have been established: amphipathic helices and hydrophobic hairpins (Thiam et al, 2013b), although other motifs can target as well (Murugesan et al, 2013). Some of these may simply bind other resident droplet proteins. …”Section: Er To Droplet Traffickingmentioningconfidence: 99%

Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation

2017Frontiers Research Topics0000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Scite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 3 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.