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. 1998 Apr 9;392(6676):569-74.
doi: 10.1038/33345.

Essential role of mouse telomerase in highly proliferative organs

H W Lee  1 , M A Blasco, G J Gottlieb, J W Horner 2nd, C W Greider, R A DePinho
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"V体育官网入口" Essential role of mouse telomerase in highly proliferative organs

VSports最新版本 - H W Lee et al. Nature. .

Abstract

We have investigated the role of the enzyme telomerase in highly proliferative organs in successive generations of mice lacking telomerase RNA. Late-generation animals exhibited defective spermatogenesis, with increased programmed cell death (apoptosis) and decreased proliferation in the testis VSports手机版. The proliferative capacity of haematopoietic cells in the bone marrow and spleen was also compromised. These progressively adverse effects coincided with substantial erosion of telomeres (the termini of eukaryotic chromosomes) and fusion and loss of chromosomes. These findings indicate an essential role for telomerase, and hence telomeres, in the maintenance of genomic integrity and in the long-term viability of high-renewal organ systems. .

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