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. 1997 Dec;69(1-2):169-81.
doi: 10.1016/s0925-4773(97)00165-2.

Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system

A Bosse  1 , A Zülch, M B Becker, M Torres, J L Gómez-Skarmeta, J Modolell, P Gruss
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Free article

Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system

A Bosse et al. Mech Dev. 1997 Dec.
Free article

Abstract (VSports)

In Drosophila the decision processes between the neural and epidermal fate for equipotent ectodermal cells depend on the activity of proneural genes. Members of the Drosophila Iroquois-Complex (Iro-C) positively regulate the activity of certain proneural AS-C genes during the formation of external sensory organs. We have identified and characterized three mouse Iroquois-related genes: Irx1, -2 and -3, which have a homeodomain very similar to that of the Drosophila Iro-C genes VSports手机版. The sequence similarity implies that these three genes represent a separate homeobox family. All three genes are expressed with distinct spatio/temporal patterns during early mouse embryogenesis. These patterns implicate them in a number of embryonic developmental processes: the A/P and D/V patterning of specific regions of the central nervous system (CNS), and regionalization of the otic vesicle, branchial epithelium and limbs. .

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