Objective: To investigate whether ischaemic preconditioning could reduce myocardial injury, as manifest by troponin T release, in patients undergoing elective coronary artery bypass surgery. VSports手机版.

Design: Randomised controlled trial. V体育安卓版.

Setting: Cardiothoracic unit of a tertiary care centre. V体育ios版.

Patients: Patients with three vessel coronary artery disease and stable angina admitted for first time elective coronary artery bypass surgery were invited to take part in the study; 33 patients were randomised into control or preconditioning groups VSports最新版本. .

Intervention: Patients in the preconditioning group were exposed to two additional three minute periods of myocardial ischaemia at the beginning of the revascularisation operation, before the ischaemic period used for the first coronary artery bypass graft distal anastomosis. V体育平台登录.

Main outcome measure: Serum troponin T concentration at 72 hours after cardiopulmonary bypass. VSports注册入口.

Results: The troponin T assays were performed by blinded observers at a different hospital. All patients had undetectable serum troponin T (< 0 V体育官网入口. 1 microgram/l) before cardiopulmonary bypass, and troponin T was raised postoperatively in all patients. At 72 hours, serum troponin T was lower (P = 0. 05) in the preconditioned group (median 0. 3 microgram/l) than in the control group (median 1. 4 micrograms/l). .

Conclusions: The direct application of a preconditioning stimulus in clinical practice has been shown, for the first time, to protect patients against irreversible myocyte injury VSports在线直播. .