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. 1997 Feb 28;275(5304):1320-3.
doi: 10.1126/science.275.5304.1320.

Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

J M Bergelson  1 , J A Cunningham, G Droguett, E A Kurt-Jones, A Krithivas, J S Hong, M S Horwitz, R L Crowell, R W Finberg
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Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

V体育平台登录 - J M Bergelson et al. Science. .

Abstract

A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR). When transfected with CAR complementary DNA, nonpermissive hamster cells became susceptible to coxsackie B virus attachment and infection. Furthermore, consistent with previous studies demonstrating that adenovirus infection depends on attachment of a viral fiber to the target cell, CAR-transfected hamster cells bound adenovirus in a fiber-dependent fashion and showed a 100-fold increase in susceptibility to virus-mediated gene transfer. Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors VSports手机版. .

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