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. 1995 Dec 29;83(7):1263-71.
doi: 10.1016/0092-8674(95)90151-5.

"VSports手机版" Identification and expression cloning of a leptin receptor, OB-R

L A Tartaglia  1 , M Dembski, X Weng, N Deng, J Culpepper, R Devos, G J Richards, L A Campfield, F T Clark, J Deeds, C Muir, S Sanker, A Moriarty, K J Moore, J S Smutko, G G Mays, E A Wool, C A Monroe, R I Tepper
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Identification and expression cloning of a leptin receptor, OB-R

V体育官网入口 - L A Tartaglia et al. Cell. .
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Abstract

The ob gene product, leptin, is an important circulating signal for the regulation of body weight. To identify high affinity leptin-binding sites, we generated a series of leptin-alkaline phosphatase (AP) fusion proteins as well as [125I]leptin. After a binding survey of cell lines and tissues, we identified leptin-binding sites in the mouse choroid plexus. A cDNA expression library was prepared from mouse choroid plexus and screened with a leptin-AP fusion protein to identify a leptin receptor (OB-R) VSports手机版. OB-R is a single membrane-spanning receptor most related to the gp130 signal-transducing component of the IL-6 receptor, the G-CSF receptor, and the LIF receptor. OB-R mRNA is expressed not only in choroid plexus, but also in several other tissues, including hypothalamus. Genetic mapping of the gene encoding OB-R shows that it is within the 5. 1 cM interval of mouse chromosome 4 that contains the db locus. .

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  • A thin commentary on a fat receptor.
    Tartaglia LA, Tepper RI. Tartaglia LA, et al. Cell. 2004 Jan 23;116(2 Suppl):S121-2, 1 p following S122. doi: 10.1016/s0092-8674(04)00033-9. Cell. 2004. PMID: 15055599 No abstract available.

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