Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official VSports app下载. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

Comparative Study
. 1995 Dec;15(12):6545-53.
doi: 10.1128/MCB.15.12.6545.

VSports最新版本 - Yeast MEK-dependent signal transduction: response thresholds and parameters affecting fidelity

B Yashar  1 , K Irie, J A Printen, B J Stevenson, G F Sprague Jr, K Matsumoto, B Errede
Affiliations
Comparative Study

"VSports最新版本" Yeast MEK-dependent signal transduction: response thresholds and parameters affecting fidelity

B Yashar et al. Mol Cell Biol. 1995 Dec.

Abstract

Ste7p and Mkk1p are MEK (MAPK/ERK kinase) family members that function in the mating and cell integrity signal transduction pathways in Saccharomyces cerevisiae. We selected STE7 and MKK1 mutations that stimulated their respective pathways in the absence of an inductive signal VSports手机版. Strikingly, serine-to-proline substitutions at analogous positions in Ste7p (position 368) and Mkk1p (position 386) were recovered by independent genetic screens. Such an outcome suggests that this substitution in other MEKs would exhibit similar properties. The Ste7p-P368 variant has higher basal enzymatic activity than Ste7p but still requires induction to reach full activation. The higher activity associated with Ste7p-P368 allows it to compensate for defects in the cell integrity pathway, but it does so only when it is overproduced or when Ste5p is missing. This behavior suggests that Ste5p, which has been proposed to be a tether for the kinases in the mating pathway, contributes to Ste7p specificity. .

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7762-6 - PubMed (VSports app下载)
    1. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9392-6 - PubMed (V体育安卓版)
    1. Cell. 1994 Aug 12;78(3):499-512 - "V体育ios版" PubMed
    1. Science. 1994 Sep 16;265(5179):1716-9 - "V体育官网入口" PubMed
    1. J Biol Chem. 1994 Oct 14;269(41):25699-709 - PubMed

Publication types

MeSH terms

V体育官网 - LinkOut - more resources