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. 1993 Nov 19;262(5137):1274-7.
doi: 10.1126/science.8235659.

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

D J Kane  1 , T A Sarafian, R Anton, H Hahn, E B Gralla, J S Valentine, T Ord, D E Bredesen
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"VSports注册入口" Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

D J Kane et al. Science. .

"VSports手机版" Abstract

The proto-oncogene bcl-2 inhibits apoptotic and necrotic neural cell death. Expression of Bcl-2 in the GT1-7 neural cell line prevented death as a result of glutathione depletion. Intracellular reactive oxygen species and lipid peroxides rose rapidly in control cells depleted of glutathione, whereas cells expressing Bcl-2 displayed a blunted increase and complete survival. Modulation of the increase in reactive oxygen species influenced the degree of cell death VSports手机版. Yeast mutants null for superoxide dismutase were partially rescued by expression of Bcl-2. Thus, Bcl-2 prevents cell death by decreasing the net cellular generation of reactive oxygen species. .

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