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. 1994 Sep 2;265(5177):1445-7.
doi: 10.1126/science.8073287.

Thrombocytopenia in c-mpl-deficient mice

A L Gurney  1 , K Carver-Moore, F J de Sauvage, M W Moore
Affiliations

Thrombocytopenia in c-mpl-deficient mice

A L Gurney et al. Science. .

"VSports在线直播" Abstract

Thrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production. The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in regulating megakaryocytopoiesis, c-mpl-deficient mice were generated by gene targeting. The c-mpl-/- mice had an 85 percent decrease in their number of platelets and megakaryocytes but had normal amounts of other hematopoietic cell types VSports手机版. These mice also had increased concentrations of circulating TPO. These results show that c-mpl specifically regulates megakaryocytopoiesis and thrombopoiesis through activation by its ligand TPO. .

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