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. 1995 Mar;71(3):448-50.
doi: 10.1038/bjc.1995.91.

Loss of heterozygosity of the oestrogen receptor gene in breast cancer

H Iwase  1 , J M Greenman, D M Barnes, L Bobrow, S Hodgson, C G Mathew
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Free PMC article

Loss of heterozygosity of the oestrogen receptor gene in breast cancer

H Iwase et al. Br J Cancer. 1995 Mar.
Free PMC article

V体育官网入口 - Abstract

DNA from 67 primary breast carcinoma biopsies has been examined for loss of heterozygosity (LOH) using the microsatellite (TA)n repeat marker positioned 1 kb upstream of the oestrogen receptor (ER) gene. Forty-seven (70. 1%) of the cases were informative; nine of these (19. 1%) were positive for LOH. In three of the nine cases, there was total loss, and in the other six cases there was a marked reduction in the intensity of signal from one allele. LOH correlated weakly with histological grade and age, but not with ER status. This result suggests that LOH of the ER gene does not have an important role in the lack of ER function in breast cancer tissues VSports手机版. .

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References (V体育安卓版)

    1. Lancet. 1992 Jan 18;339(8786):139-43 - PubMed
    1. Histopathology. 1991 Nov;19(5):403-10 - PubMed
    1. Genes Chromosomes Cancer. 1992 Mar;4(2):113-21 - PubMed
    1. Int J Cancer. 1993 Jan 2;53(1):11-6 - PubMed
    1. Clin Biochem. 1992 Dec;25(6):407-14 - PubMed

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