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. 1982 Feb;42(2):535-9.

Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice

J A Houghton, P J Houghton, A A Green
  • PMID: 7034923

"VSports在线直播" Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice

J A Houghton et al. Cancer Res. 1982 Feb.

"VSports在线直播" Abstract

Xenografts derived from the neoplastic tissues of children with rhabdomyosarcoma have been used in immune-deprived mice to examine the efficacy of agents known to be active against this disease, and in others that received either limited or no clinical evaluation. Two models were derived; xenografts were established from tumors obtained from either (a) untreated patients or (b) from patients who had become refractory to conventional therapy. Model a identified as being effective each of these clinically used agents: vincristine, dactinomycin, cyclophosphamide, and doxorubicin; mitomycin C and 5-(3,3-dimethyl-1-triazeno)-2-methylimidazole-4-carboxamide also showed activity, as did busulfan in one tumor line. Tumors derived from refractory patients were significantly less responsive to all agents examined. VSports手机版.

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