Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or VSports app下载. mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 1972 Jun 1;135(6):1334-50.
doi: 10.1084/jem.135.6.1334.

"V体育ios版" Rejection of ascites tumor allografts. I. Isolation, characterization, and in vitro reactivity of peritoneal lymphoid effector cells from BALB-c mice immune to EL4 leukosis

G Berke, K A Sullivan, B Amos

"V体育平台登录" Rejection of ascites tumor allografts. I. Isolation, characterization, and in vitro reactivity of peritoneal lymphoid effector cells from BALB-c mice immune to EL4 leukosis

G Berke et al. J Exp Med. .

Abstract

Peritoneal exudate cells (PEC), obtained after the rejection of EL4 leukemia by BALB/c mice, are much more effective in the specific in vitro destruction of (51)Cr-labeled EL4 cells than are spleen, thymus, lymph node, or peripheral blood lymphocytes. The presence of a large number of effector cells at the site of graft rejection is reflected in the potent cytolytic activity seen in vitro VSports手机版. Effector cells temporarily lose cytolytic reactivity when treated with trypsin but regain reactivity with time. This recovery occurs in normal as well as in immune serum. The destructive reactivity of PEC is increased when macrophages are removed. The remaining population of nonadherent PEC is composed primarily of small- to medium-sized lymphocytes. Complex tissue culture media are not needed, but there is a definite requirement for serum. The required serum component is heat stable, nondialyzable, and is not consumed during the reaction. The use of an ascites allograft system made these observations possible and permitted the isolation of those host cells intimately associated with rejection. .

PubMed Disclaimer

"V体育官网入口" References

    1. Adv Cancer Res. 1970;13:63-95 - PubMed
    1. Ann N Y Acad Sci. 1956 Mar 14;63(5):640-61 - PubMed
    1. Immunology. 1968 Feb;14(2):181-96 - "V体育安卓版" PubMed
    1. Ann N Y Acad Sci. 1960 May 31;87:273-92 - PubMed
    1. Adv Immunol. 1969;11:117-93 - PubMed

MeSH terms