A Mendelian Randomisation Analysis Reveals No Relationship Between Periodontitis and Coronary Atherosclerosis (VSports在线直播)

Zhengrui Li¹, Qi Wang², Xufeng Huang³, Yinteng Wu⁴, Rao Fu¹, Xutao Wen¹, Ji'An Liu¹, Yuanguo Chen⁵, Ying Liu⁶, Ling Zhang⁷

Affiliations

¹ Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinical Research Center for Oral Diseases, Shanghai, China; Shanghai Key Laboratory of Stomatology, Shanghai, China; Shanghai Research Institute of Stomatology, Shanghai, China; Shanghai Center of Head and Neck Oncology Clinical and Translational Science, Shanghai, China.
² Jiangsu University, Zhenjiang, China.
³ Faculty of Dentistry, University of Debrecen, Debrecen, Hungary.
⁴ Department of Orthopedic and Trauma Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, China.
⁵ Ya'an People's Hospital, Department of Cardiovascular Medicine Ya'an, Sichuan, China.
⁶ Department of Cardiology, Sixth Medical Center, PLA General Hospital, Beijing, China. Electronic address: liuying@www.qiuluzeuv.cn.
⁷ Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinical Research Center for Oral Diseases, Shanghai, China; Shanghai Key Laboratory of Stomatology, Shanghai, China; Shanghai Research Institute of Stomatology, Shanghai, China; Shanghai Center of Head and Neck Oncology Clinical and Translational Science, Shanghai, China. Electronic address: topgun1128@www.qiuluzeuv.cn.

PMID: 38431470
PMCID: PMC11287172
DOI: 10.1016/j.identj.2024.01.027

"V体育ios版" A Mendelian Randomisation Analysis Reveals No Relationship Between Periodontitis and Coronary Atherosclerosis

Zhengrui Li et al. Int Dent J. 2024 Aug.

. 2024 Aug;74(4):705-712.

doi: 10.1016/j.identj.2024.01.027. Epub 2024 Mar 2.

Authors

Zhengrui Li¹, Qi Wang², Xufeng Huang³, Yinteng Wu⁴, Rao Fu¹, Xutao Wen¹, Ji'An Liu¹, Yuanguo Chen⁵, Ying Liu⁶, Ling Zhang⁷

Affiliations

¹ Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinical Research Center for Oral Diseases, Shanghai, China; Shanghai Key Laboratory of Stomatology, Shanghai, China; Shanghai Research Institute of Stomatology, Shanghai, China; Shanghai Center of Head and Neck Oncology Clinical and Translational Science, Shanghai, China.
² Jiangsu University, Zhenjiang, China.
³ Faculty of Dentistry, University of Debrecen, Debrecen, Hungary.
⁴ Department of Orthopedic and Trauma Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, China.
⁵ Ya'an People's Hospital, Department of Cardiovascular Medicine Ya'an, Sichuan, China.
⁶ Department of Cardiology, Sixth Medical Center, PLA General Hospital, Beijing, China. Electronic address: liuying@www.qiuluzeuv.cn.
⁷ Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinical Research Center for Oral Diseases, Shanghai, China; Shanghai Key Laboratory of Stomatology, Shanghai, China; Shanghai Research Institute of Stomatology, Shanghai, China; Shanghai Center of Head and Neck Oncology Clinical and Translational Science, Shanghai, China. Electronic address: topgun1128@www.qiuluzeuv.cn.

Abstract

Objectives: Growing evidence appears to intimate a profound connection between periodontitis and coronary atherosclerosis (CA), yet the existence of a causal relationship remains unclear VSports手机版. Through the implementation of Mendelian randomization analysis, we further evaluated the potential causal link between chronic/acute periodontitis (CP/AP) and CA. .

Methods: Utilizing genome-wide association study (GWAS) summary statistics, we incorporated periodontitis data derived from European samples (n1 = 198,441; n2 = 195,762) and CA data from 61,194 cases. We conducted a 2 sample, bidirectional Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW) method as the main analytical approach. Supplementary analyses were executed through MR Egger, Weighted median (WM), IVW, Simple mode, and Weighted mode approaches. V体育安卓版.

Results: The IVW analysis revealed no significant causal relationship between CA and periodontitis (CA-CP: OR = 2. 110, 95% CI = 0. 208-21 V体育ios版. 317, P = . 527; CA-AP: OR = 0. 414, 95% CI = 0. 051-3. 384, P = . 644). Similarly, the bidirectional analysis did not identify impact of periodontitis on CA (OR = 1. 000, 95% CI = 0. 999-1. 001, P = . 953). The supplementary analyses corroborated these findings. .

Conclusions: While studies highlighting a correlation between periodontitis and CA, our comprehensive analysis does not corroborate a causal association between periodontitis and CA. Further research is needed to elucidate other potential shared mechanisms and causal evidence between periodontitis and CA VSports最新版本. .

Keywords: Coronary atherosclerosis; Inverse-variance weighted; Mendelian randomization; Periodontitis V体育平台登录. .

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V体育安卓版 - Conflict of interest statement

Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig 1 — **Fig. 1**
Schematic illustration of the 2-sample Mendelian randomization study investigating the relationship between periodontitis (chronic/acute) and coronary atherosclerosis. The depicted design proposes a bidirectional association between periodontitis and coronary atherosclerosis, accounting for potential confounding factors.

Fig 2 — **Fig. 2**
A and B. Forest plots depicting the causal influence of single nucleotide polymorphisms (SNPs) associated with coronary atherosclerosis on chronic periodontitis (A) and acute periodontitis (B). (The results calculated by Mendelian randomization using a single SNP are summarized and visualized. The red line below is the Mendelian randomization results including all SNPS. It can be seen that the results of a single SNP are positive and negative, indicating that the effect is not significant. The axis represents the effect size(β) of each SNP.) C and D. Scatter plots illustrate the genetic associations between coronary atherosclerosis, chronic periodontitis (C), and acute periodontitis (D). (Each point on the scatter plot represents an SNP, with the horizontal coordinate being the SNP's effect on exposure and the vertical coordinate being the SNP's effect on outcome. It is possible to observe whether the stronger the SNP effect on exposure, the stronger the SNP effect on outcome. At the same time, the scatter plot includes the analysis results of the 5 methods.)

Fig 3 — **Fig. 3**
A. The forest plot illustrates the causal impact of single nucleotide polymorphisms (SNPs) associated with periodontitis on coronary atherosclerosis. (It can be seen that the results of a single SNP are positive and negative, indicating that the effect is not significant.) B. Genetic association between periodontitis and coronary atherosclerosis. There was no finding that the stronger the SNP effect on exposure, the stronger the SNP effect on outcome.

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References

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A Mendelian Randomisation Analysis Reveals No Relationship Between Periodontitis and Coronary Atherosclerosis (VSports在线直播)

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"V体育ios版" A Mendelian Randomisation Analysis Reveals No Relationship Between Periodontitis and Coronary Atherosclerosis

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V体育安卓版 - Conflict of interest statement

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