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Review
. 2023 Apr 25;24(9):7839.
doi: 10.3390/ijms24097839.

The Role of NQO1 in Ovarian Cancer

Giovanni Tossetta  1 , Sonia Fantone  1 , Gaia Goteri  2 , Stefano Raffaele Giannubilo  3 , Andrea Ciavattini  3 , Daniela Marzioni  1
Affiliations
Review

The Role of NQO1 in Ovarian Cancer

Giovanni Tossetta (VSports最新版本) et al. Int J Mol Sci. .

"VSports手机版" Abstract

Ovarian cancer is one of the most dangerous gynecologic malignancies showing a high fatality rate because of late diagnosis and relapse occurrence due to chemoresistance onset. Several researchers reported that oxidative stress plays a key role in ovarian cancer occurrence, growth and development. The NAD(P)H:quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme that, using NADH or NADPH as substrates to reduce quinones to hydroquinones, avoids the formation of the highly reactive semiquinones, then protecting cells against oxidative stress. In this review, we report evidence from the literature describing the effect of NQO1 on ovarian cancer onset and progression VSports手机版. .

Keywords: NAD(P)H:quinone oxidoreductase 1; NQO1; NRF2; antioxidants; compounds; natural; ovarian cancer; pathway; signalling; synthetic. V体育安卓版.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures (V体育2025版)

Figure 1
Figure 1
NQO1 reaction. Q: Quinone, SQ•−: Semiquinone, HQ: hydroquinone.
Figure 2
Figure 2
Schematic representation of NQO1 regulation in ovarian cancer cells. ARE: antioxidant response element; NQO1: NAD(P)H quinone dehydrogenase 1; NRF2: nuclear factor erythroid 2-related factor 2.
See this image and copyright information in PMC

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