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Review
. 2023 Jan 4:12:1049888.
doi: 10.3389/fonc.2022.1049888. eCollection 2022.

"VSports注册入口" The function of natural compounds in important anticancer mechanisms

Yang Nan  1 , Hongchan Su  1 , Bo Zhou  1 , Shumin Liu  2
Affiliations
Review

"VSports最新版本" The function of natural compounds in important anticancer mechanisms

Yang Nan et al. Front Oncol. .

Abstract

The existence of malignant tumors has been a threat to human life, health, and safety. Although the rapid development of radiotherapy, drug therapy, surgery, and local therapy has improved the quality of life of tumor patients, there are still some risks. Natural compounds are widely used in cancer because they are easy to obtain, have a good curative effects and have no obvious side effects, and play a vital role in the prevention and treatment of various cancers. Phenolic, flavonoids, terpenoids, alkaloids, and other natural components of traditional Chinese medicine have certain anti-tumor activities, which can promote apoptosis, anti-proliferation, anti-metastasis, inhibit angiogenesis, change the morphology of cancer cells and regulate immune function, etc. , and have positive effects on breast cancer, liver cancer, lung cancer, gastric cancer, rectal cancer and so on. To better understand the effects of natural compounds on cancer, this paper screened out four important pathways closely related to cancer, including cell death and immunogenic cell death, immune cells in the tumor microenvironment, inflammation and related pathways and tumor metastasis, and systematically elaborated the effects of natural compounds on cancer. VSports手机版.

Keywords: anticancer natural compounds; cell death; immune cells; potential cancer target; tumor metastasis. V体育安卓版.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Effects of natural compounds on cancer from four aspects: apoptosis and immunogenic cell death, immune cells in the tumor microenvironment, inflammation and related pathways, and tumor metastasis.
Figure 2
Figure 2
Effects of natural compounds on apoptosis and ICD mechanisms.
Figure 3
Figure 3
The effect mechanism of natural compounds on immune cells in the tumor microenvironment.
Figure 4
Figure 4
Effects of natural compounds on inflammation and related pathways. Inflammatory cytokines and chemokines themselves, as well as JAK-STAT and NF-KB signaling pathways, interact to promote cancer cell growth.
Figure 5
Figure 5
Effect mechanism of natural compounds on tumor metastasis. Cancer cells can proliferate indefinitely, lose their original cell function, and migrate easily. As the blood circulates, they cause cancer to metastasize. Natural compounds can inhibit tumor metastasis and exert anticancer effects through a variety of mechanisms, including 1. Epithelial-mesenchymal transition (EMT); 2. Circulating tumor cells (CTC); 3. Cancer stem cells (CSC) 4.RNA regulation.
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