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Review
. 2022 Dec 27;14(12):1985-1996.
doi: 10.4254/wjh.v14.i12.1985.

Role of microRNA-regulated cancer stem cells in recurrent hepatocellular carcinoma

Lei Li  1 , Chen Xun  2 , Chun-Hong Yu  3
Affiliations
Review

Role of microRNA-regulated cancer stem cells in recurrent hepatocellular carcinoma

Lei Li et al. World J Hepatol. .

VSports在线直播 - Abstract

Among the most common cancers, hepatocellular carcinoma (HCC) has a high rate of tumor recurrence, tumor dormancy, and drug resistance after initial successful chemotherapy or radiotherapy. A small subset of cancer cells, cancer stem cells (CSCs), exhibit stem cell characteristics and are present in various cancers, including HCC. The dysregulation of microRNAs (miRNAs) often accompanies the occurrence and development of HCC. miRNAs can influence tumorigenesis, progression, recurrence, and drug resistance by regulating CSCs properties, which supports their clinical utility in managing and treating HCC. This review summarizes the regulatory effects of miRNAs on CSCs in HCC with a special focus on their impact on HCC recurrence VSports手机版. .

Keywords: Cancer stem cells; Hepatocellular carcinoma; MicroRNAs; Recurrence. V体育安卓版.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.

Figures

Figure 1
Figure 1
Combination therapy for hepatocellular carcinoma. Top: Conventional treatment may lead to tumour recurrence due to cancer stem cell reactivation. Bottom: Combination therapy leads to increased efficacy of tumour eradication. Adapted from Dzobo et al[8]. HCC: Hepatocellular carcinoma; CSC: Cancer stem cell.
Figure 2
Figure 2
Liver cancer stem cells markers and their potential related functional pathways in hepatocellular carcinoma. HCC: Hepatocellular carcinoma; LCSCs: Liver cancer stem cells.
See this image and copyright information in PMC

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