<kbd date-time="YrMjL"></kbd><del id="UWKzaan"></del> Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. VSports app下载.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Review
. 2022 Sep 20;14(19):3889.
doi: 10.3390/nu14193889.

Emerging Role of Nicotinamide Riboside in Health and Diseases

Chiranjeev Sharma  1 , Dickson Donu  1 , Yana Cen  1   2
Affiliations
Review

VSports app下载 - Emerging Role of Nicotinamide Riboside in Health and Diseases

Chiranjeev Sharma et al. Nutrients. .

Abstract

Among all the NAD+ precursors, nicotinamide riboside (NR) has gained the most attention as a potent NAD+-enhancement agent. This recently discovered vitamin, B3, has demonstrated excellent safety and efficacy profiles and is orally bioavailable in humans. Boosting intracellular NAD+ concentrations using NR has been shown to provide protective effects against a broad spectrum of pathological conditions, such as neurodegenerative diseases, diabetes, and hearing loss. In this review, an integrated overview of NR research will be presented VSports手机版. The role NR plays in the NAD+ biosynthetic pathway will be introduced, followed by a discussion on the synthesis of NR using chemical and enzymatic approaches. NR's effects on regulating normal physiology and pathophysiology will also be presented, focusing on the studies published in the last five years. .

Keywords: COVID-19; dietary supplements; health; nicotinamide riboside; vitamin B3. V体育安卓版.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
NAD+ biosynthetic pathways in mammalian cells. NA: nicotinic acid; NAM: nicotinamide; NR: nicotinamide riboside; NMN: nicotinamide mononucleotide; NaMN: nicotinic acid mononucleotide; NaAD: nicotinic acid adenine dinucleotide; NRH: reduced nicotinamide riboside; NMNH: reduced nicotinamide mononucleotide; QPRTase: quinolinate phosphoribosyltransferase; NMNAT: nicotinamide mononucelotide adenylyltransferase; NaPRTase: nicotinic acid phosphoribosyl transferase; NAMPT: nicotinamide phosphoribosyl transferase; NRK: nicotinamide riboside kinase; PNP: purine nucleoside phosphorylase; AK: adenosine kinase; NQO2: NRH: quinone oxidoreductase 2.
Figure 2
Figure 2
NR synthesis: glycosylation of NAM and acetylated-D-ribofuranose. (A) Synthetic scheme of β-NR triflate developed by Kirihata et al. [53]; (B) Neighboring group participation leads to the formation of β-NR as the major anomer.
Figure 3
Figure 3
Synthetic scheme of β-NR triflate developed by Sauve et al. [39,55].
Figure 4
Figure 4
Schematic representation of the chemo-enzymatic synthesis of 13C, 18O-NR.
See this image and copyright information in PMC

References

    1. Azzini E., Raguzzini A., Polito A. A Brief Review on Vitamin B12 Deficiency Looking at Some Case Study Reports in Adults. Int. J. Mol. Sci. 2021;22:9694. doi: 10.3390/ijms22189694. - "VSports最新版本" DOI - PMC - PubMed
    1. Smith T.J., Johnson C.R., Koshy R., Hess S.Y., Qureshi U.A., Mynak M.L., Fischer P.R. Thiamine deficiency disorders: A clinical perspective. Ann. N. Y. Acad. Sci. 2021;1498:9–28. doi: 10.1111/nyas.14536. - DOI - PMC - PubMed
    1. Holubiec P., Leonczyk M., Staszewski F., Lazarczyk A., Jaworek A.K., Rojas-Pelc A. Pathophysiology and clinical management of pellagra—A review. Folia Med. Cracov. 2021;61:125–137. - PubMed
    1. Trapani S., Rubino C., Indolfi G., Lionetti P. A Narrative Review on Pediatric Scurvy: The Last Twenty Years. Nutrients. 2022;14:684. doi: 10.3390/nu14030684. - DOI - PMC - PubMed
    1. Dewett D., Lam-Kamath K., Poupault C., Khurana H., Rister J. Mechanisms of vitamin A metabolism and deficiency in the mammalian and fly visual system. Dev. Biol. 2021;476:68–78. doi: 10.1016/j.ydbio.2021.03.013. - DOI (VSports最新版本) - PMC - PubMed

"V体育ios版" Publication types

MeSH terms

VSports app下载 - LinkOut - more resources