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Review
. 2021 May 11;13(5):1609.
doi: 10.3390/nu13051609.

VSports注册入口 - Botanicals in Postmenopausal Osteoporosis

Wojciech Słupski  1 , Paulina Jawień  1 , Beata Nowak  1
Affiliations
Review

Botanicals in Postmenopausal Osteoporosis

Wojciech Słupski et al. Nutrients. .

Abstract

Osteoporosis is a systemic bone disease characterized by reduced bone mass and the deterioration of bone microarchitecture leading to bone fragility and an increased risk of fractures. Conventional anti-osteoporotic pharmaceutics are effective in the treatment and prophylaxis of osteoporosis, however they are associated with various side effects that push many women into seeking botanicals as an alternative therapy. Traditional folk medicine is a rich source of bioactive compounds waiting for discovery and investigation that might be used in those patients, and therefore botanicals have recently received increasing attention. The aim of this review of literature is to present the comprehensive information about plant-derived compounds that might be used to maintain bone health in perimenopausal and postmenopausal females VSports手机版. .

Keywords: botanicals; herbs; menopause; osteoporosis. V体育安卓版.

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Conflict of interest statement

The authors declare no conflict of interest.

VSports在线直播 - Figures

Figure 1
Figure 1
Schematic diagram representing regulation of osteoblast and osteoclast differentiation. BMP—bone morphogenic protein, BMSC—bone marrow-derived mesenchymal stem cells, c-FMS—colony-stimulating factor-1 receptor, IGF—insulin-like growth factor, M-CSF—macrophage colony-stimulating factor, OB—osteoblast, OC—osteoclast, OPG—osteoprotegerin, PGFD—platelet-derived growth factor, pre-OB—pre-osteoblasts, pre-OC—pre-osteoclasts, PTH—parathyroid hormone, RANK—Receptor Activator for Nuclear Factor κB, RANKL—Receptor Activator for Nuclear Factor κB Ligand, TGFβ—tumour growth factor β.
Figure 2
Figure 2
Influence of oestrogens on osteoblast and osteoclast function, and bone turnover. FasL—Fas Ligand, NFκB—Nuclear Factor κB, OPG—osteoprotegerin, RANKL—Receptor Activator for Nuclear Factor κB Ligand, ↑—increased, ↓—decreased
Figure 3
Figure 3
Schematic diagram representing the influence of isoflavones on proliferation, differentiation and activity of osteoclasts and osteoblasts. BMP2—bone morphogenic protein 2, ER—oestrogen receptor, MAPK/ERK—mitogen-activated protein kinase/extracellular signal-regulated kinases signalling pathway, OPG—osteoprotegerin, Osx—Osteoblast-specific transcription factor Osterix, PI3K/Akt- phosphoinositide-3-kinase/serine-threonine kinase signalling pathway, —Receptor Activator for Nuclear Factor κB, RANKL—Receptor Activator for Nuclear Factor κB Ligand, Runx2—Runt-related transcription factor 2, ↑—increased, ↓—decreased, (-)—inhibited, (+)—activated
Figure 4
Figure 4
Schematic diagram of the antiosteoporotic activity of various plants and their components. BMP—bone morphogenic protein, MAPK—mitogen-activated protein kinase, OB—osteoblast, OPG—osteoprotegerin, RANK—Receptor Activator for Nuclear Factor κB, RANKL—Receptor Activator for Nuclear Factor κB Ligand, Runx2—Runt-related transcription factor 2, ↓ decreased, (-)—inhibited, (+) activated
See this image and copyright information in PMC

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