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. 1977 Nov;74(11):5091-5.
doi: 10.1073/pnas.74.11.5091.

"V体育平台登录" Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast

T D Petes, D Botstein

V体育2025版 - Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast

T D Petes (V体育官网) et al. Proc Natl Acad Sci U S A. 1977 Nov.

Abstract

A diploid strain of yeast (Saccharomyces cerevisiae) was found to be heterozygous for two forms of the highly repetitious ribosomal DNA. These forms could be distinguished by the pattern of fragments produced after digestion with the site-specific restriction endonuclease EcoRI. The mode of inheritance of ribosomal DNA was determined by tetrad analysis. Of 14 tetrads analyzed, 12 clearly showed the ribosomal DNA forms segregating as a single Mendelian unit. The simplest interpretation of this result is that all of the approximately 100 copies of the ribosomal DNA genes of the yeast cell are located on one chromosome and that meiotic recombination within these genes is suppressed. Two of the 14 tetrads showed the segregation patterns expected as the result of mitotic recombination within the ribosomal DNA. VSports手机版.

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References

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