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Meta-Analysis
. 2020 May 28:148:e106.
doi: 10.1017/S095026882000117X.

Association of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis

Jingqi Zhang  1 , Jing Wu  1 , Xiaohua Sun  2 , Hong Xue  3 , Jianguo Shao  3 , Weihua Cai  3 , Yang Jing  1 , Ming Yue  4 , Chen Dong  1
Affiliations
Meta-Analysis

Association of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis

Jingqi Zhang et al. Epidemiol Infect. .

Abstract

Hypertension is a common comorbidity in COVID-19 patients. However, the association of hypertension with the severity and fatality of COVID-19 remain unclear. In the present meta-analysis, relevant studies reported the impacts of hypertension on SARS-CoV-2 infection were identified by searching PubMed, Elsevier Science Direct, Web of Science, Wiley Online Library, Embase and CNKI up to 20 March 2020. As the results shown, 12 publications with 2389 COVID-19 patients (674 severe cases) were included for the analysis of disease severity. The severity rate of COVID-19 in hypertensive patients was much higher than in non-hypertensive cases (37 VSports手机版. 58% vs 19. 73%, pooled OR: 2. 27, 95% CI: 1. 80-2. 86). Moreover, the pooled ORs of COVID-19 severity for hypertension vs. non-hypertension was 2. 21 (95% CI: 1. 58-3. 10) and 2. 32 (95% CI: 1. 70-3. 17) in age <50 years and ⩾50 years patients, respectively. Additionally, six studies with 151 deaths of 2116 COVID-19 cases were included for the analysis of disease fatality. The results showed that hypertensive patients carried a nearly 3. 48-fold higher risk of dying from COVID-19 (95% CI: 1. 72-7. 08). Meanwhile, the pooled ORs of COVID-19 fatality for hypertension vs. non-hypertension was 6. 43 (95% CI: 3. 40-12. 17) and 2. 66 (95% CI: 1. 27-5. 57) in age <50 years and ⩾50 years patients, respectively. Neither considerable heterogeneity nor publication bias was observed in the present analysis. Therefore, our present results provided further evidence that hypertension could significantly increase the risks of severity and fatality of SARS-CoV-2 infection. .

Keywords: COVID-19; SARS-CoV-2; fatality; hypertension; severity. V体育安卓版.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1.
Fig. 1.
Flow diagram of the studies included in the meta-analysis.
Fig. 2.
Fig. 2.
Meta-analysis of the associations between hypertension and COVID-19 severity. (a) Forest plot of the COVID-19 severity for comparison between hypertensive and non-hypertensive patients; (b) Sensitivity analysis of the COVID-19 severity for comparison between hypertensive and non-hypertensive patients after excluding any single study one-at-a-time.
Fig. 3.
Fig. 3.
Subgroup analysis of the associations between hypertension and risk of COVID-19 severity (age <50 years and age ⩾50years).
Fig. 4.
Fig. 4.
Meta-analysis of the associations between hypertension and COVID-19 fatality. (a) Forest plot of the COVID-19 fatality for comparison between hypertensive and non-hypertensive patients; (b) Sensitivity analysis of the COVID-19 fatality for comparison between hypertensive and non-hypertensive patients after excluding any single study one-at-a-time.
Fig. 5.
Fig. 5.
Subgroup analysis of the associations between hypertension and risk of COVID-19 fatality (age <50 years and age ⩾50 years).
See this image and copyright information in PMC

References

    1. Craig AT, Heywood AE and Hall J (2020) Risk of COVID-19 importation to the Pacific islands through global air travel. Epidemiology & Infection 148, e71. - PMC - PubMed
    1. Chen TM et al. (2020) A mathematical model for simulating the phase-based transmissibility of a novel coronavirus. Infectious Diseases of Poverty 9, 24. - PMC - PubMed
    1. Coronavirus Outbreak. Available at https://www.worldometers.info/coronavirus/ (Accessed 02 April 2020).
    1. Guo T et al. (2020) Cardiovascular implications of fatal outcomes of patients with Coronavirus disease 2019 (COVID-19). JAMA Cardiology 2020, e201017. - PMC - PubMed
    1. Guan WJ et al. (2020) Comorbidity and its impact on 1590 patients with Covid-19 in China: A nationwide analysis. European Respiratory Journal 55, 2000547. - PMC - PubMed

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MeSH terms