Background: Carcinogens released from indoor burning of solid fuels are believed to enter the bloodstream and to be metabolized in breast and cervical tissues. Little evidence exists about the relationship of solid fuel use from heating with breast and cervical cancer. VSports手机版.

Objectives: To examine the association of solid heating fuel use with breast and cervical cancer mortality V体育安卓版. .

Methods: This study included female participants aged 30-79 years who were enrolled in the China Kadoorie Biobank during 2004-2008 from 10 diverse regions across China. During a 10 V体育ios版. 2-year median follow-up, 177 breast cancer deaths and 113 cervical cancer deaths were documented. Multivariable Cox regression models yielded adjusted hazard ratios (HRs) for the associations of self-reported long-term heating fuel exposure with two cancer deaths. Stratified analyses were used to assess effect modification. .

Results: We included 236,116 participants for breast cancer analyses and 228,795 for cervical cancer analyses. Compared with non-solid fuel use, the fully adjusted HRs of cervical cancer deaths were 1 VSports最新版本. 75 (0. 91-3. 38) for wood use, 2. 23 (1. 09-4. 59) for mixed fuel (coal and wood) use. No evident relationship was observed for breast cancer deaths. Cervical cancer risk increased with the duration of solid fuel use (P for trend = 0. 041). Elevated cervical cancer risk was observed in post-menopausal women (HR 2. 01, 1. 01-4. 03), not in pre-menopausal women (HR 0. 77, 0. 56-2. 31) (P for heterogeneity = 0. 004); and in those aged ≥50 years (HR 2. 56, 1. 17-5. 86), not in those aged < 50 years (HR 0. 69, 0. 26-1. 84) (P < 0. 001). .

Conclusion: Indoor solid fuel combustion for heating may be associated with a higher risk for cervical cancer death, but not for breast cancer. The strength of the association increased with the duration of exposure and was modified by age and menopause status. V体育平台登录.