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. 2020 Mar;115(3):381-387.
doi: 10.14309/ajg.0000000000000498.

"V体育ios版" Demographic and Lifestyle Risk Factors for Gastric Intestinal Metaplasia Among US Veterans

Mimi C Tan  1 , Niharika Mallepally  2 , Yan Liu  1   3 , Hashem B El-Serag  2   3 , Aaron P Thrift  4   5
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"VSports注册入口" Demographic and Lifestyle Risk Factors for Gastric Intestinal Metaplasia Among US Veterans

Mimi C Tan et al. Am J Gastroenterol. 2020 Mar.

Abstract

Objectives: The risk of noncardia gastric cancer is increased in the presence of gastric intestinal metaplasia. We aimed to identify demographic and lifestyle factors independently associated with the risk of gastric intestinal metaplasia VSports手机版. .

Methods: We used data from a cross-sectional study of patients attending primary care and endoscopy clinics at the Michael E. DeBakey VA Medical Center in Houston, Texas, between February 2008 and August 2013. All patients completed standardized questionnaires and underwent endoscopy with gastric mapping biopsies. Gastric intestinal metaplasia cases included patients with intestinal metaplasia on any noncardia gastric biopsy; we defined extensive gastric intestinal metaplasia as antrum and corpus involvement. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariate logistic regression models. V体育安卓版.

Results: We identified 423 cases with gastric intestinal metaplasia and 1,796 controls without gastric intestinal metaplasia. Older age (vs <60 years: 60-69 years AdjOR, 1. 50; 95% CI, 1. 17-1. 93; ≥70 years AdjOR, 2. 12; 95% CI, 1 V体育ios版. 48-3. 04), male sex (AdjOR, 2. 76; 95% CI, 1. 50-5. 10), nonwhite race/ethnicity (vs non-Hispanic white: Hispanic, AdjOR, 2. 66; 95% CI, 1. 89-3. 76; black, AdjOR, 2. 36; 95% CI, 1. 85-3. 02), and current smoking status (AdjOR, 1. 78; 95% CI, 1. 29-2. 48) were independently associated with gastric intestinal metaplasia. These risk factors remained statistically significantly associated with gastric intestinal metaplasia after adjusting for Helicobacter pylori infection, and their effect sizes were larger for associations with extensive gastric intestinal metaplasia compared with focal gastric intestinal metaplasia. .

Discussion: Older age, male sex, nonwhite race/ethnicity, and current smoking status were the nonendoscopic factors independently associated with gastric intestinal metaplasia in a predominantly nonimmigrant US population. VSports最新版本.

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References

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    1. Anderson WF, Rabkin CS, Turner N, et al. The changing face of noncardia gastric cancer incidence among US non-Hispanic Whites. J Natl Cancer Inst 2018;110(6):608–15.
    1. Wang Z, Graham DY, Khan A, et al. Incidence of gastric cancer in the USA during 1999 to 2013: A 50-state analysis. Int J Epidemiol 2018;47(3):966–75.
    1. Tan MC, Wang Z, El-Serag HB, et al. Mo1721-increasing incidence of advanced non-cardia gastric cancers among younger Hispanics in the United States. Gastroenterology 2019;156(6):S-821.
    1. Balakrishnan M, George R, Sharma A, et al. An investigation into the recent increase in gastric cancer in the USA. Dig Dis Sci 2018;63(6):1613–9.

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