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Review
. 2019 Oct 24;11(11):1631.
doi: 10.3390/cancers11111631.

Understanding and Targeting Apoptotic Pathways in Ovarian Cancer

Linah F Al-Alem  1   2 , Andrew T Baker  3   4 , Unnati M Pandya  5   6 , Eric L Eisenhauer  7   8   9 , Bo R Rueda  10   11   12
Affiliations
Review

"V体育官网入口" Understanding and Targeting Apoptotic Pathways in Ovarian Cancer

Linah F Al-Alem et al. Cancers (Basel). .

Abstract

Ovarian cancer cells evade the immune system as well as chemotherapeutic and/or biologic treatments through inherent or acquired mechanisms of survival and drug resistance. Depending on the cell type and the stimuli, this threshold can range from external forces such as blunt trauma to programmed processes such as apoptosis, autophagy, or necroptosis. This review focuses on apoptosis, which is one form of programmed cell death. It highlights the multiple signaling pathways that promote or inhibit apoptosis and reviews current clinical therapies that target apoptotic pathways in ovarian cancer VSports手机版. .

Keywords: apoptosis; chemoresistance; clinical trials; glycosylation; miRNA; ovarian cancer V体育安卓版. .

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Cell death mechanisms: A cellular damaging or stressful event could push the cell toward recovery or one of the different cell death pathways including necrosis, apoptosis and autophagy.
Figure 2
Figure 2
Simplified overview of extrinsic and intrinsic apoptosis pathways and inhibitor of apoptosis (IAP) function with drug targets.
Figure 3
Figure 3
A summary of caspases identified and their major roles in the apoptotic cascade. The caspases identified under the execution stage (red) are typically the more heavily studied in cancer due to their presumed direct effect on apoptosis. The intrinsic apoptotic pathway culminates in the release of Cytochrome C, which then activates initiating caspases (e.g., Caspase 9. This activation then leads to apoptosis via execution caspases (e.g., Caspase-3).
Figure 4
Figure 4
Proteins under each class of IAPs.
See this image and copyright information in PMC

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