PD-L1 is a double-edged sword in colorectal cancer: the prognostic value of PD-L1 depends on the cell type expressing PD-L1

Hsiang-Ling Ho^{1

2}, Teh-Ying Chou^{1

2

3}, Shung-Haur Yang^{4

5

6}, Jeng-Kai Jiang^{4

5}, Wei-Shone Chen^{4

5}, Yee Chao^{7

4}, Hao-Wei Teng^{8

9

10}

Affiliations

¹ Division of Molecular Pathology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
² Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan.
³ Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
⁴ School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan.
⁵ Division of Colon and Rectum Surgery, Department of Surgery, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan.
⁶ Department of Surgery, National Yang-Ming University Hospital, Yilan, Taiwan.
⁷ Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan.
⁸ Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. hwteng1971@www.qiuluzeuv.cn.
⁹ Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan. hwteng1971@www.qiuluzeuv.cn.
¹⁰ School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan. hwteng1971@www.qiuluzeuv.cn.

PMID: 31129768
PMCID: PMC11810398
DOI: 10.1007/s00432-019-02942-y

PD-L1 is a double-edged sword in colorectal cancer: the prognostic value of PD-L1 depends on the cell type expressing PD-L1

VSports最新版本 - Hsiang-Ling Ho et al. J Cancer Res Clin Oncol. 2019 Jul.

. 2019 Jul;145(7):1785-1794.

doi: 10.1007/s00432-019-02942-y. Epub 2019 May 25.

Authors

Hsiang-Ling Ho^{1

2}, Teh-Ying Chou^{1

2

3}, Shung-Haur Yang^{4

5

6}, Jeng-Kai Jiang^{4

5}, Wei-Shone Chen^{4

5}, Yee Chao^{7

4}, Hao-Wei Teng^{8

9

10}

VSports - Affiliations

¹ Division of Molecular Pathology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
² Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan.
³ Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
⁴ School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan.
⁵ Division of Colon and Rectum Surgery, Department of Surgery, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan.
⁶ Department of Surgery, National Yang-Ming University Hospital, Yilan, Taiwan.
⁷ Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan.
⁸ Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. hwteng1971@www.qiuluzeuv.cn.
⁹ Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan. hwteng1971@www.qiuluzeuv.cn.
¹⁰ School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan. hwteng1971@www.qiuluzeuv.cn.

PMID: 31129768
PMCID: PMC11810398 (VSports)
DOI: VSports app下载 - 10.1007/s00432-019-02942-y

Abstract

Purpose: To investigate the associations between programmed cell death ligand-1 (PD-L1) on tumor cells (TCs) or PD-L1 on tumor-infiltrating immune cells (TIICs) and the microsatellite instability (MSI) status in colorectal cancer (CRC). VSports手机版.

Methods: In total, 238 CRC patients were enrolled V体育安卓版. PD-L1 expression and MSI status were studied by immunohistochemical staining and polymerase chain reaction. The χ2 test was used to compare characteristics. The Kaplan-Meier method was used for survival analysis. Cox proportional hazards models were used to determine the prognostic influence of clinicopathological factors. .

Results: Eighteen patients (7. 6%) were had MSI-high (MSI-H) CRC. The number of patients with PD-L1 expression on TCs, stromal TIICs and intraepithelial TIICs was 13 (5. 5%), 64 (26. 9%) and 45 (18. 9%), respectively. The MSI-H phenotype was significantly associated with younger age, right sidedness, mucinous component, high grade, stromal TIICs expressing PD-L1 (P = 0. 042) and intraepithelial TIICs expressing PD-L1 (P < 0. 001), but not TCs expressing PD-L1. PD-L1-expressing TCs were an independent marker of poor prognosis [hazard ratio (HR) = 3. 387, P = 0 V体育ios版. 003], and PD-L1-expressing stromal TIICs were an independent marker of good prognosis (HR = 0. 551, P < 0. 001). .

Conclusions: PD-L1-expressing TCs were a marker of poor prognosis; in contrast, PD-L1-expressing TIICs were a marker of good prognosis. The MSI-H phenotype was associated with the presence of PD-L1-expressing TIICs, but not of PD-L1-expressing TCs. VSports最新版本.

Keywords: Colorectal cancer; Immunotherapy; Microsatellite instability; PD-L1. V体育平台登录.

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Conflict of interest statement

The authors Hsiang-Ling Ho, Teh-Ying Chou, Shung-Haur Yang, Jeng-Kai Jiang, Wei-Shone Chen, Yee Chao, and Hao-Wei Teng declare that they have no conflict of interest.

Figures

**Fig. 1**
Representative images of PD-L1 immunostaining in tumor cells (TCs) (a), intraepithelial tumor-infiltrating immune cells (TIICs) (b), and stromal TIICs of grade 3 (c), grade 2 (d), grade 1 (e) and grade 0 (f) samples. (Original magnification × 400; Inset: higher magnification)

**Fig. 2**
a Overall survival (OS) of patients with colorectal cancer (CRC) stratified by the microsatellite instability (MSI) status; b OS of patients with CRC stratified by PD-L1 expression on tumor cells (TCs); c OS of patients with CRC stratified by PD-L1 expression on stromal tumor-infiltrating immune cells (TIICs); d OS of patients with CRC stratified by PD-L1 expression on intraepithelial TIICs

See this image and copyright information in PMC

References

1. Bacher JW et al (2015) Improved detection of microsatellite instability in early colorectal lesions. PLoS One 10:e0132727. 10.1371/journal.pone.0132727 - VSports在线直播 - PMC - PubMed
1. Barber DL et al (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439:682–687. 10.1038/nature04444 - PubMed
1. Brenner H, Kloor M, Pox CP (2014) Colorectal cancer. Lancet 383:1490–1502. 10.1016/S0140-6736(13)61649-9 - PubMed
1. Callea M et al (2015) Differential expression of PD-L1 between primary and metastatic sites in clear-cell renal cell carcinoma. Cancer Immunol Res 3:1158–1164. 10.1158/2326-6066.cir-15-0043 - PMC - PubMed
1. Droeser RA et al (2013) Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. Eur J Cancer 49:2233–2242. 10.1016/j.ejca.2013.02.015 - PubMed

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PD-L1 is a double-edged sword in colorectal cancer: the prognostic value of PD-L1 depends on the cell type expressing PD-L1

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PD-L1 is a double-edged sword in colorectal cancer: the prognostic value of PD-L1 depends on the cell type expressing PD-L1

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