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. 2019 Jul;110(7):2180-2188.
doi: 10.1111/cas.14034. Epub 2019 May 27.

circMAN1A2 could serve as a novel serum biomarker for malignant tumors

Chun-Mei Fan  1   2   3 , Jin-Peng Wang  2 , Yan-Yan Tang  2 , Jin Zhao  2 , Shu-Yi He  2 , Fang Xiong  1 , Can Guo  2 , Bo Xiang  2 , Ming Zhou  2 , Xiao-Ling Li  2 , Yong Li  2   4 , Gui-Yuan Li  1   2   3 , Wei Xiong  1   2   3 , Zhao-Yang Zeng  1   2   3
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circMAN1A2 could serve as a novel serum biomarker for malignant tumors

Chun-Mei Fan et al. Cancer Sci. 2019 Jul.

V体育安卓版 - Abstract

Novel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNAs act as important regulators in cancers at the transcriptional and posttranscriptional levels. The circular RNA circMAN1A2 is highly expressed in nasopharyngeal carcinoma according to our previous RNA sequencing data; however, the expression and functions of circMAN1A2 in cancers are still obscure. Therefore, in this study, we evaluated the expression of circMAN1A2 in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of circMAN1A2 were detected by quantitative real-time PCR, and the correlations of clinical features with circMAN1A2 expression were analyzed by χ2 tests. Receiver operating characteristic curves were used to evaluate the clinical applications of circMAN1A2. The results showed that circMAN1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0. 911, 0. 779, 0. 734, 0. 694, and 0. 645, respectively, indicating the good diagnostic value of circMAN1A2. Overall, our findings suggested that circMAN1A2 could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of circMAN1A2 in the pathogenesis of cancer VSports手机版. .

Keywords: circular RNA; diagnosis; malignant cancer; receiver operating characteristic; serum biomarker. V体育安卓版.

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Figures

Figure 1
Figure 1
Expression of circMAN1A2 in sera from patients with nasopharyngeal carcinoma (NPC) was detected by SYBR quantitative PCR (qPCR) and Quantitative PCR using TaqMan. A, Quantitative PCR (qPCR) using SYBR was used to detect the expression levels of circMAN1A2 in the sera from patients with NPC (Tumor, T) compared with that in the normal control group (Normal, N). P < 0.001. B, Quantitative PCR using TaqMan was used to detect the expression levels of circMAN1A2 in the sera of patients with NPC compared with that in normal controls. P < 0.001. C, Correlation analysis between Quantitative PCR (qPCR) using SYBR and Quantitative PCR using TaqMan. GraphPad Prism 5 software was used to analyze the correlations between the 2 experimental methods. P < 0.001, r = 0.919. D, Further analysis with larger sample sizes, P < 0.001
Figure 2
Figure 2
circMAN1A2 was highly expressed in the sera of patients with oral cancer, thyroid cancer, ovarian cancer, or lung cancer. A‐D, Relative expression of circMAN1A2 in oral cancer (A), thyroid cancer (B), ovarian cancer (C), and lung cancer (D). P < 0.01
Figure 3
Figure 3
Receiver operating characteristic (ROC) curve data for the clinical diagnostic value of circMAN1A2. A‐E, ROC curves of circMAN1A2 in the serum of patients with nasopharyngeal carcinoma (NPC) (A), oral cancer (B), thyroid cancer (C), ovarian cancer (D), or lung cancer (E)
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