<var date-time="AjjxRU"></var> Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or VSports app下载. mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2019 Dec;47(1):1224-1233.
doi: 10.1080/21691401.2019.1593999.

Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis

Meiyin Zhang  1 , Bairong Xia  1 , Ye Xu  1 , Yongjian Zhang  1 , Jin Xu  2 , Ge Lou  1
Affiliations
Free article

Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis

Meiyin Zhang et al. Artif Cells Nanomed Biotechnol. 2019 Dec.
Free article

Abstract (V体育安卓版)

In this study, we identified hsa_circ_0051240 was significantly increased in ovarian cancer (OC) tissues. Our results indicated that silencing of hsa_circ_0051240 inhibited OC cell proliferation, migration and invasion in vitro, and also prevented OC tumour formation in vivo. In addition, the inhibitory effects by blockage of hsa_circ_0051240 could be attenuated by the miR-637 inhibitor. Furthermore, we also identified that hsa_circ_0051240 act as a sponge of miR-637, and miR-637 directly targeted KLK4 mRNA in OC cells VSports手机版. Altogether, hsa_circ_0051240 promotes OC cell proliferation, migration and invasion through inhibiting the miR-637/KLK4 axis. Therefore, these results demonstrated that the hsa_circ_0051240/miR-637/KLK4 axis might serve as a therapeutic target for OC treatment. .

Keywords: Kallikrein 4; circular RNA; has_circ_0051240; microRNA-637; ovarian cancer V体育安卓版. .

PubMed Disclaimer

MeSH terms

LinkOut - more resources