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Review
. 2019 Mar 15;11(3):367.
doi: 10.3390/cancers11030367.

Circulating Tumour Cells (CTC), Head and Neck Cancer and Radiotherapy; Future Perspectives

Vanathi Perumal  1   2   3   4 , Tammy Corica  5 , Arun M Dharmarajan  6   7   8 , Zhonghua Sun  9 , Satvinder S Dhaliwal  10 , Crispin R Dass  11   12 , Joshua Dass  13
Affiliations
Review

Circulating Tumour Cells (CTC), Head and Neck Cancer and Radiotherapy; Future Perspectives

Vanathi Perumal et al. Cancers (Basel). .

Abstract

Head and neck cancer is the seventh most common cancer in Australia and globally. Despite the current improved treatment modalities, there is still up to 50⁻60% local regional recurrence and or distant metastasis. High-resolution medical imaging technologies such as PET/CT and MRI do not currently detect the early spread of tumour cells, thus limiting the potential for effective minimal residual detection and early diagnosis. Circulating tumour cells (CTCs) are a rare subset of cells that escape from the primary tumour and enter into the bloodstream to form metastatic deposits or even re-establish themselves in the primary site of the cancer VSports手机版. These cells are more aggressive and accumulate gene alterations by somatic mutations that are the same or even greater than the primary tumour because of additional features acquired in the circulation. The potential application of CTC in clinical use is to acquire a liquid biopsy, by taking a reliable minimally invasive venous blood sample, for cell genotyping during radiotherapy treatment to monitor the decline in CTC detectability, and mutational changes in response to radiation resistance and radiation sensitivity. Currently, very little has been published on radiation therapy, CTC, and circulating cancer stem cells (CCSCs). The prognostic value of CTC in cancer management and personalised medicine for head and neck cancer radiotherapy patients requires a deeper understanding at the cellular level, along with other advanced technologies. With this goal, this review summarises the current research of head and neck cancer CTC, CCSC and the molecular targets for personalised radiotherapy response. .

Keywords: cf DNA; circulating cancer stem cells; circulating tumour cells; ctDNA; radiotherapy V体育安卓版. .

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V体育官网 - Conflict of interest statement

The authors declare they have no competing financial interests. V体育ios版.

Figures

Figure 1
Figure 1
PET scan of Male pyriform fossa squamous cell carcinoma stage T4aN2bM0 patient without surgery, treated with radical radiotherapy delivery 70Gy/35# over 7 weeks followed by cisplatin 100 mg/msq given on week 1, week 4 and week 7 of radiotherapy. (A) Left panel blue circle showing the tumour spot before treatment on the 23 October 2014; (B) Right blue circle panel showing the antitumor effect of radical radio chemotherapy after treatment, showing no regional palpable lymphadenopathy, oral capsule was clear, showing no local recurrence, patient follow up after two years on 11 May 2017.
Figure 2
Figure 2
CT scans of the neck region in pyriform fossa squamous cell carcinoma patient showing the tumour area and no local recurrence. (A) Right panel blue circle showing clear palpable lymphadenopathy. (B) Left panel blue circle showing the tumour regression after two years, nasendoscopy also showed no local recurrence.
Figure 3
Figure 3
Potential of head and neck circulating tumour cell research in radiation oncology.
Figure 4
Figure 4
New developments and progress towards unexplored CTC-Cancer research. Figure generated using free smart draw templates and examples program.
See this image and copyright information in PMC

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