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. 2019 Feb 28:10:139.
doi: 10.3389/fphar.2019.00139. eCollection 2019.

"V体育安卓版" The Prognostic and Clinicopathological Roles of PD-L1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis

Yan Li  1   2 , Meizhi He  2 , Yaoyao Zhou  2 , Chen Yang  3 , Shuyi Wei  2 , Xiaohui Bian  2 , Odong Christopher  3 , Lang Xie  1
Affiliations

The Prognostic and Clinicopathological Roles of PD-L1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis

Yan Li et al. Front Pharmacol. .

Abstract (V体育2025版)

Background: Studies evaluating the prognostic significance of programmed death-ligand 1 (PD-L1) expression in colorectal cancer (CRC) are limited and remain controversial. This meta-analysis was conducted in order to evaluate the clinicopathological and prognostic significance of PD-L1 expression in CRC patients. Methods: A comprehensive search was performed against the Medline/PubMed, Embase, Cochrane Library, Web of Science (WoS) and Scopus databases. Data were extracted with name of the first author, year of publication, country of origin, tumor type, number of cases, staining method, cut-off values, PD-L1 positive expression, clinicopathological parameters, outcome, and quality assessment score, and statistical analysis was conducted using Review Manager Version 5. 3 (Revman the Cochrane Collaboration; Oxford, England) and STATA version 14 (Stata Corporation; College Station, TX, USA). Results: Ten studies were included in this meta-analysis, in which the pooled hazard ratio (HR) showed that PD-L1 expression in tumor cells was significantly associated with a poor overall survival (HR = 1. 50, 95% CI 1. 05-2. 13, P = 0. 03). The pooled HR for disease-free survival (DFS) indicated that PD-L1 expression was significantly associated with shorter DFS (HR = 2. 57, 95% CI 1. 40-4. 75, P = 0. 002). The pooled odds ratios (ORs) showed that PD-L1 expression was associated with poor differentiation (OR = 3. 47, 95% CI 1. 37-8. 77, P = 0. 008) and right colon cancer (OR = 2. 38, 95% CI 1. 57-3. 60, P < 0. 0001). However, the expression of PD-L1 was independent of gender, age, tumor size, tumor stage, lymph node metastasis, and tumor-node metastasis stage. Conclusion: This meta-analysis indicated that a high level of PD-L1 expression might be a biomarker for a poor prognosis in CRC patients. This information may be helpful for clinicians to stratify CRC patients for anti-PD-1/PD-L1 therapy, particularly patients with microsatellite instability high (MSI-H). VSports手机版.

Keywords: PD-L1/ PD-1; clinicopathological; colorectal cancer; meta-analysis; prognostic. V体育安卓版.

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Figures (V体育ios版)

Figure 1
Figure 1
Flow diagram of the study selection process in this meta-analysis.
Figure 2
Figure 2
Forest plot of 10 studies evaluating the association between PD-L1 expression and prognostic parameters in CRC patients (A: OS in TC; B: IRS≥4 as cut-off value; C: DFS in TC; D: RFS in TC; E: RFS in TILs).
Figure 3
Figure 3
Forest plots for the association of PD-L1 expression with clinicopathological features in CRC patients (A: gender; B: age; C: cancer location; D: differentiation; E: tumor size; F: T stage; G: lymph node metastasis; H: TNM stage).
Figure 4
Figure 4
Egger's and Begg's funnel plot with 95% CI for OS publication bias in the included six studies.
Figure 5
Figure 5
Funnel blot visualizing a potential publication bias of PD-L1 expression with gender and T stage (A: gender; B: T stage).
See this image and copyright information in PMC

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