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. 2018 Dec;12(6):697-706.
doi: 10.1007/s11684-018-0655-7. Epub 2018 Nov 13.

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway

Jun Song  1   2   3 , Yeping Huang  1 , Wenjian Zheng  4 , Jing Yan  1 , Min Cheng  5 , Ruxing Zhao  2 , Li Chen  2 , Cheng Hu  6 , Weiping Jia  7
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"VSports注册入口" Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway

Jun Song et al. Front Med. 2018 Dec.

"V体育平台登录" Abstract

Oxidative stress induced by free fatty acid aggravates endothelial injury, which leads to diabetic cardiovascular complications. Reduction of intracellular oxidative stress may attenuate these pathogenic processes. The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelial injury. This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation of reactive oxygen species (ROS) and further explored the underlying molecular mechanisms VSports手机版. We found that resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells. Resveratrol also induced endothelial cell autophagy, which mediated the effect of resveratrol on ROS reduction. Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway. Taken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway. Thus, the induction of autophagy by resveratrol may provide a novel therapeutic candidate for cardioprotection in metabolic syndrome. .

Keywords: AMPK; autophagy; mTOR; reactive oxygen species; resveratrol. V体育安卓版.

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