Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official VSports app下载. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2018 Jul 2;501(4):1034-1040.
doi: 10.1016/j.bbrc.2018.05.104. Epub 2018 May 19.

UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis

Junrong Wang  1 , Cong Ye  2 , Junbao Liu  3 , Yubo Hu  1
Affiliations

VSports在线直播 - UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis

Junrong Wang et al. Biochem Biophys Res Commun. .

Abstract

Increasing evidence has demonstrated the involvement of dysregulated long non-coding RNAs (lncRNAs) in chemoresistance acting as potential oncogenes or tumor suppressors in various cancers. Nevertheless, the profound molecular mechanisms of lncRNAs in ovarian cancer (OC) chemoresistance is not well elucidated. The objective of this work was to investigate the role and molecular mechanisms of urothelial carcinoma associated 1 (UCA1) in paclitaxel (PTX) resistance in OC. Our results indicated that UCA1 was significantly up-regulated in PTX-resistant OC cells (SKOV3/PTX and HeyA-8/PTX) compared with their parental cells (SKOV3 and HeyA-8). Functionally, UCA1 knockdown sensitized SKOV3/PTX and HeyA-8/PTX cells to PTX through enhancing PTX-induced apoptosis. Mechanistically, UCA1 silencing induced PTX sensitivity of SKOV3/PTX and HeyA-8/PTX cells by de-repressing ABCB1 through sponging miR-129. Collectively, our study elaborated a novel UCA1/miR-129/ABCB1 regulatory axis underlying PTX resistance of OC cells, providing a potential therapeutic target for OC VSports手机版. .

Keywords: ABCB1; Ovarian cancer; Paclitaxel resistance; UCA1; miR-129. V体育安卓版.

PubMed Disclaimer

MeSH terms

Substances

LinkOut - more resources