Objective: Epilepsy is characterized by a relevant epidemiological and clinical burden. In the extant literature, an increased risk of seizures has been described in several inflammatory/autoimmune disorders, including systemic lupus erythematosus (SLE) VSports手机版. However, so far, relatively few and small size-based studies have been conducted. We aimed to investigate the link between seizure and SLE utilizing a large sample of subjects and extensive data analysis. .

Methods: Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of epilepsy in a cross-sectional study V体育安卓版. Chi-square and t tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services. .

Results: The study included 5,018 patients with SLE and 25,090 age- and gender-frequency-matched controls. The proportion of epilepsy was found significantly higher among SLE patients (4. 03 vs. 0 V体育ios版. 87%, p < 0. 001). Using logistic regression, adjusting for multiple confounding factors, older age (≥70 years) resulted as negative predictor (OR 0. 42 [95% CI 0. 27-0. 62], p <0. 001), whereas the presence of SLE was a positive predictor of epilepsy (OR 4. 70 [95% CI 3. 94-5. 82], p < 0. 001). Interaction between SLE and elderly age resulted in high OR of 5. 47 for epilepsy (95% CI 2. 53-11. 9). .

Conclusion: Our study confirms the higher prevalence of epilepsy in SLE patients VSports最新版本. Physicians should be aware of such findings and have a lower threshold for suspecting epileptic seizures in these patients. Further studies are needed to better elucidate the mechanisms by which SLE favors the insurgence of seizures. .