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. 2017 Nov;19(11):1348-1357.
doi: 10.1038/ncb3623. Epub 2017 Oct 9.

A non-coding function of TYRP1 mRNA promotes melanoma growth

David Gilot  1 , Mélodie Migault  1 , Laura Bachelot  1 , Fabrice Journé  2 , Aljosja Rogiers  3   4 , Emmanuelle Donnou-Fournet  1 , Ariane Mogha  1 , Nicolas Mouchet  1 , Marie-Laure Pinel-Marie  5 , Bernard Mari  6 , Tristan Montier  7   8 , Sébastien Corre  1 , Arthur Gautron  1 , Florian Rambow  3   4 , Petra El Hajj  2 , Rania Ben Jouira  9 , Sophie Tartare-Deckert  9 , Jean-Christophe Marine  3   4 , Brice Felden  5 , Ghanem Ghanem  2 , Marie-Dominique Galibert  1   10
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Free article

A non-coding function of TYRP1 mRNA promotes melanoma growth

David Gilot et al. Nat Cell Biol. 2017 Nov.
Free article

Abstract (V体育官网)

Competition among RNAs to bind miRNA is proposed to influence biological systems. However, the role of this competition in disease onset is unclear. Here, we report that TYRP1 mRNA, in addition to encoding tyrosinase-related protein 1 (TYRP1), indirectly promotes cell proliferation by sequestering miR-16 on non-canonical miRNA response elements. Consequently, the sequestered miR-16 is no longer able to repress its mRNA targets, such as RAB17, which is involved in melanoma cell proliferation and tumour growth. Restoration of miR-16 tumour-suppressor function can be achieved in vitro by silencing TYRP1 or increasing miR-16 expression. Importantly, TYRP1-dependent miR-16 sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16-binding sites on TYRP1 mRNA VSports手机版. Together, our findings assign a pathogenic non-coding function to TYRP1 mRNA and highlight miRNA displacement as a promising targeted therapeutic approach for melanoma. .

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