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. 2015 Jun;6(3):364-374.
doi: 10.14740/wjon931w. Epub 2015 Jun 12.

Correlation of NQO1 and Nrf2 in Female Genital Tract Cancer and Their Precancerous Lesions (Cervix, Endometrium and Ovary)

Nisreen Abdel Tawab Abdel Gaber Osman  1 , Nehad M R Abd El-Maqsoud  1 , Saad Abdelnaby A El Gelany  2
Affiliations

Correlation of NQO1 and Nrf2 in Female Genital Tract Cancer and Their Precancerous Lesions (Cervix, Endometrium and Ovary) (VSports在线直播)

Nisreen Abdel Tawab Abdel Gaber Osman et al. World J Oncol. 2015 Jun.

Abstract

Background: NAD (P) H/quinone oxidoreductase 1 (NQO1) is a metabolizing enzyme that detoxifies chemical stressors and antioxidants VSports手机版. Nuclear factor erythroid 2-related factor 2 (NrF2) is an important transcriptional activator involved in the cellular defense mechanisms against oxidative stress. .

Methods: The immunohistochemical expression of NQO1 and Nrf2 in 80 cervical, 80 endometrial and 100 ovarian specimens with different lesions was studied. Then we study the relation of both NQO1 and Nrf2 expression and clinicopathological features of carcinoma cases. V体育安卓版.

Results: Immunohistochemical stain showed that NQO1 and Nrf2 were highly expressed in carcinoma compared with normal and precancerous lesions. Significant positive correlations were found between the mean expression of NQO1 and Nrf2 in different lesions V体育ios版. Moreover, there was significant correlation between the high level of NQO1 and Nrf2 expression and high tumor grade in cervical and endometrial carcinoma cases. Nrf2 expression was significant with advanced stage in endometrial and ovarian carcinomas. .

Conclusions: NQO1 and Nrf2 might be new biomarkers for early diagnosis and prognostic evaluation as well as being targets for therapy in patients with tumors in female genital tract. VSports最新版本.

Keywords: Cervical carcinoma; Endometrial carcinoma; NQO1; Nrf2; Ovarian carcinoma V体育平台登录. .

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Figures (VSports在线直播)

Figure 1
Figure 1
NQO1 protein expression in different lesions using IHC (× 400, DAB was used as the chromogen and hematoxylin as counterstain). (a) NQO1 protein was weak in normal cervical epithelium. (b) NQO1 protein staining was moderate positive in LSIL. (c) NQO1 protein showed diffuse and strong cytoplasmic-positive staining in HSIL. (d) NQO1 was strong positive in grade I cervical SCC. (e) NQO1 protein was weak in proliferative endometrium. (f) NQO1 was moderate positive in simple EH. (g) NQO1 was strong positive in atypical EH. (h) NQO1 was strong positive in EC. (i) NQO1 was negative in normal ovarian epithelium. (j) NQO1 was positive mucinous cystadenoma. (k) NQO1 was moderate positive in borderline serous tumor. (l) NQO1 was strong positive in ovarian carcinoma.
Figure 2
Figure 2
Nrf2 protein expression in different lesions using IHC (× 400, DAB was used as the chromogen and hematoxylin as counterstain). (a) Nrf2 protein was weak in normal cervical epithelium. (b) Nrf2 protein staining was moderate positive in LSIL. (c) Nrf2 protein showed moderate nuclear-positive staining in HSIL, but weak positive in adjacent normal cervical glands. (d) Nrf2 was strong positive in grade II cervical SCC. (e) Nrf2 protein was positive in proliferative endometrium. (f) Nrf2 was moderate positive in simple EH. (g) Nrf2 was moderate positive in atypical EH. (h) Nrf2 was strong positive in EC. (i) Nrf2 was negative in normal ovarian epithelium. (j) Nrf2 was positive serous cystadenoma. (k) Nrf2 was moderate positive in borderline serous tumor. (l) Nrf2 was strong positive in ovarian carcinoma.
Figure 3
Figure 3
NQO1 expression box plots (a) in different cervical lesions; (b) in different endometrial lesions; (c) in different ovarian lesions. Horizontal lines in the boxes represent the median value of each group. The top and bottom edges of the boxes indicate the score values from 75th percentile and the 25th percentile respectively. Whiskers represent the highest and lowest values. The range is shown as a vertical line.
Figure 4
Figure 4
NrF2 expression box plots (a) in different cervical lesions; (b) in different endometrial lesions; (c) in different ovarian lesions. Horizontal lines in the boxes represent the median value of each group. The top and bottom edges of the boxes indicate the score values from 75th percentile and the 25th percentile respectively. Whiskers represent the highest and lowest values. The range is shown as a vertical line.
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