<small lang="DA0FynVJ"></small>
"VSports注册入口" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2017 Aug 30;7(1):9973.
doi: 10.1038/s41598-017-10556-y.

Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: a Nationwide Population-based Study

Tae-Min Rhee  1 , Ji Hyun Lee  2 , Eue-Keun Choi  3 , Kyung-Do Han  4 , HyunJung Lee  1 , Chan Soon Park  1 , Doyeon Hwang  1 , So-Ryoung Lee  1 , Woo-Hyun Lim  5 , Si-Hyuck Kang  6 , Myung-Jin Cha  1 , Youngjin Cho  6 , Il-Young Oh  6 , Seil Oh  1
Affiliations

Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: a Nationwide Population-based Study (V体育2025版)

Tae-Min Rhee et al. Sci Rep. .

"VSports最新版本" Abstract

Psoriasis increases the risk of atrial fibrillation (AF) and thromboembolic events (TE). There is limited information on the effect of psoriasis severity on AF and TE. In this study, psoriasis patients were enrolled from the Korean National Insurance Service-National Sample Cohort (2004-2008). Diagnosis and disease severity were determined from claims data. Newly diagnosed non-valvular AF and TE were identified during a 9. 6-year follow-up. The effect of psoriasis severity on AF and TE was evaluated. We identified 13,385 psoriasis patients (1,947 with severe psoriasis). Severe psoriasis significantly increased the risk of AF (adjusted hazard ratio [HRadjust] 1. 44 [95% confidence interval (CI) 1. 14-1. 82], p = 0. 002) and TE (HRadjust 1 VSports手机版. 26 [95% CI 1. 07-1. 47], p = 0. 005); mild psoriasis did not show any significant effects. Results were similar after propensity-score matching. Risk increments of AF and TE were prominent in patients with greater cardiovascular risk. A possible limitation of our study is that it has a retrospective design, and the effect of unmeasured confounders and risk of misclassification could bias the results. To conclude, our results showed that severe, but not mild, psoriasis significantly increased AF and TE risk. AF surveillance and active stroke prevention would be beneficial in such cases. .

PubMed Disclaimer

VSports注册入口 - Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flow of Cohort Establishment and Follow-Up. This study was a 10-year retrospective cohort study established from the Korean nationwide health insurance claim data. Abbreviations: AF, atrial fibrillation.
Figure 2
Figure 2
Comparison of Cumulative Incidence of Atrial Fibrillation and Thromboembolic Events According to the Severity of Psoriasis. Kaplan-Meier curves with cumulative hazards of atrial fibrillation (A) and thromboembolic events (B) compared by severity of psoriasis are presented. The adjusted hazard ratios were calculated by multivariable Cox regression models, including age over 65, gender, income level, resident area, hypertension, diabetes, dyslipidemia, congestive heart failure, peripheral arterial disease, prior history of stroke and myocardial infarction as covariates. Abbreviations: CI, confidence interval; HR, hazard ratio; N/A, non-applicable.
Figure 3
Figure 3
Subgroup Analyses for Atrial Fibrillation Risk in Psoriasis Patients. The effects of psoriasis on the risk of AF were shown to be weaker in subgroups with well-known CV risk factors than those without. However, the absolute increases of incidence rates were still much higher in risky subgroups. Abbreviations: CHF, congestive heart failure; CI, confidence interval; cardiovascular, cardiovascular; DM, diabetes mellitus; HR, hazard ratio; HTN, hypertension; MI, myocardial infarction.
See this image and copyright information in PMC

References

    1. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009;361:496–509. doi: 10.1056/NEJMra0804595. - VSports在线直播 - DOI - PubMed
    1. Kang SH, et al. Underweight is a risk factor for atrial fibrillation: A nationwide population-based study. Int J Cardiol. 2016;215:449–456. doi: 10.1016/j.ijcard.2016.04.036. - DOI - PubMed
    1. Mallbris L, Granath F, Hamsten A, Stahle M. Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol. 2006;54:614–621. doi: 10.1016/j.jaad.2005.11.1079. - DOI - PubMed
    1. Yeung H, et al. Psoriasis severity and the prevalence of major medical comorbidity: a population-based study. JAMA Dermatol. 2013;149:1173–1179. doi: 10.1001/jamadermatol.2013.5015. - DOI - PMC - PubMed
    1. Abuabara K, et al. Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the U.K. Br J Dermatol. 2010;163:586–592. doi: 10.1111/j.1365-2133.2010.09941.x. - DOI - PMC - PubMed

Publication types

MeSH terms