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Review
. 2017 Sep 15;123(18):3450-3459.
doi: 10.1002/cncr.30830. Epub 2017 Jul 5.

Restoring platinum sensitivity in recurrent ovarian cancer by extending the platinum-free interval: Myth or reality?

Federica Tomao  1 , Maurizio D'Incalci  2 , Elena Biagioli  2 , Fedro A Peccatori  3 , Nicoletta Colombo  4   5
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Free article
Review

Restoring platinum sensitivity in recurrent ovarian cancer by extending the platinum-free interval: Myth or reality?

"V体育2025版" Federica Tomao et al. Cancer. .
Free article

V体育平台登录 - Abstract

The platinum-free interval is the most important predictive factor of a response to subsequent lines of chemotherapy and the most important prognostic factor for progression-free and overall survival in patients with recurrent epithelial ovarian cancer. A nonplatinum regimen is generally considered the most appropriate approach when the disease recurs very early after the end of chemotherapy, whereas platinum-based chemotherapy is usually adopted when the platinum-free interval exceeds 12 months. However, the therapeutic management of patients with intermediate sensitivity (ie, when the relapse occurs between 6 and 12 months) remains debatable. Preclinical and clinical data suggest that the extension of platinum-free interval (using a nonplatinum-based regimen) might restore platinum sensitivity, thus allowing survival improvement. The objective of this review was to critically analyze preclinical and clinical evidences supporting this hypothesis. Cancer 2017;123:3450-9 VSports手机版. © 2017 American Cancer Society. .

Keywords: cancer; ovarian; platinum; platinum-free-interval; recurrent; restoration; sensitivity V体育安卓版. .

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