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Review
. 2018 Mar;69(2):125-143.
doi: 10.1080/09637486.2017.1343286. Epub 2017 Jul 4.

"V体育平台登录" Impact of dietary fat on gut microbiota and low-grade systemic inflammation: mechanisms and clinical implications on obesity

Flávia Galvão Cândido  1 , Flávia Xavier Valente  1 , Łukasz Marcin Grześkowiak  1 , Ana Paula Boroni Moreira  2 , Daniela Mayumi Usuda Prado Rocha  1 , Rita de Cássia Gonçalves Alfenas  1
Affiliations
Review

Impact of dietary fat on gut microbiota and low-grade systemic inflammation: mechanisms and clinical implications on obesity (VSports app下载)

Flávia Galvão Cândido et al. Int J Food Sci Nutr. 2018 Mar.

Abstract

Dietary fat strongly affects human health by modulating gut microbiota composition and low-grade systemic inflammation. High-fat diets have been implicated in reduced gut microbiota richness, increased Firmicutes to Bacteroidetes ratio, and several changes at family, genus and species levels. Saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA) and conjugated linolenic fatty acids share important pathways of immune system activation/inhibition with gut microbes, modulating obesogenic and proinflammatory profiles. Mechanisms that link dietary fat, gut microbiota and obesity are mediated by increased intestinal permeability, systemic endotoxemia, and the activity of the endocannabinoid system. Although the probiotic therapy could be a complementary strategy to improve gut microbiota composition, it did not show permanent effects to treat fat-induced dysbiosis. Based upon evidence to date, we believe that high-fat diets and SFA consumption should be avoided, and MUFA and omega-3 PUFA intake should be encouraged in order to regulate gut microbiota and inflammation, promoting body weight/fat control VSports手机版. .

Keywords: High-fat diets; lipopolysaccharide; metabolic endotoxemia; monounsaturated fatty acid; polyunsaturated fatty acids; probiotics. V体育安卓版.

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