Background & aims: A new hepatocellular carcinoma risk prediction model, PAGE-B, which includes age, gender and platelet count as constituent variables, has recently been proposed in Caucasian chronic hepatitis B patients VSports手机版. We validated PAGE-B model and compared its accuracy with that of conventional risk prediction models in Asian chronic hepatitis B patients. .

Methods: Chronic hepatitis B patients treated with entecavir or tenofovir were consecutively recruited. The performance of PAGE-B and three conventional risk prediction models (CU-HCC, GAG-HCC and REACH-B) were analysed. V体育安卓版.

Results: A total of 1092 chronic hepatitis B patients (668 men, 61. 2%) were selected between August 2006 and January 2015. The mean age was 48 years. During the follow-up period (median, 43. 6 months), 36 (3. 3%) patients developed hepatocellular carcinoma. Older age (hazard ratio [HR]=1. 077), male gender (HR=3. 676) and lower platelet count (HR=0. 984) were independent predictors of hepatocellular carcinoma development. The PAGE-B showed similar area under receiver operating characteristic curves (AUROCs) to GAG-HCC and CU-HCC at 3 years (0 V体育ios版. 777 vs 0. 793 and 0. 743, respectively; all P>. 05) and 5 years (0. 799 vs 0. 803 and 0. 744, respectively; all P>. 05), whereas the AUROCs of PAGE-B were significantly higher than those of the REACH-B (0. 602 at 3 years and 0. 572 at 5 years, P<. 05). .

Conclusions: Our study demonstrated that PAGE-B is applicable to Asian chronic hepatitis B patients receiving ETV or TDF therapy. The PAGE-B showed similar predictive performance to GAG-HCC and CU-HCC VSports最新版本. .