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. 2017 Jun;49(6):953-958.
doi: 10.1038/ng.3842. Epub 2017 Apr 17.

Identification of six new genetic loci associated with atrial fibrillation in the Japanese population

Siew-Kee Low  1   2 , Atsushi Takahashi  1   3 , Yusuke Ebana  4 , Kouichi Ozaki  5   6 , Ingrid E Christophersen  7   8   9 , Patrick T Ellinor  7 ; AFGen Consortium; Soichi Ogishima  10 , Masayuki Yamamoto  10 , Mamoru Satoh  11 , Makoto Sasaki  11 , Taiki Yamaji  12 , Motoki Iwasaki  12 , Shoichiro Tsugane  13 , Keitaro Tanaka  14 , Mariko Naito  15 , Kenji Wakai  15 , Hideo Tanaka  16   17 , Tetsushi Furukawa  4 , Michiaki Kubo  18 , Kaoru Ito  5 , Yoichiro Kamatani  1 , Toshihiro Tanaka  5   19
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Identification of six new genetic loci associated with atrial fibrillation in the Japanese population

Siew-Kee Low et al. Nat Genet. 2017 Jun.

Abstract

Atrial fibrillation is the most common cardiac arrhythmia and leads to stroke. To investigate genetic loci associated with atrial fibrillation in the Japanese population, we performed a genome-wide association study (GWAS) that included 8,180 atrial fibrillation cases and 28,612 controls with follow-up in an additional 3,120 cases and 125,064 controls. We replicated previously reported loci and identified six new loci, near the KCND3, PPFIA4, SLC1A4-CEP68, HAND2, NEBL and SH3PXD2A genes. Five of the six new loci were specifically associated with atrial fibrillation in the Japanese population after comparing our data to those from individuals of European ancestry, suggesting that there might be different genetic factors affecting susceptibility across ancestry groups. Our study discovered variants in the HAND2, KCND3 and NEBL genes, which are relevant to atrial fibrillation susceptibility. The involvement of PPFIA4 and SH3PXD2A in axon guidance also suggested a role in disease pathogenesis. Our findings may contribute to a better understanding of atrial fibrillation susceptibility and pathogenesis VSports手机版. .

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