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. 2016 Sep;14(9):671-676.
doi: 10.1016/S1875-5364(16)30079-6.

Epimedium koreanum Nakai and its main constituent icariin suppress lipid accumulation during adipocyte differentiation of 3T3-L1 preadipocytes

Yunk-Yung Han  1 , Mi-Young Song  2 , Min-Sub Hwang  3 , Ji-Hye Hwang  1 , Yong-Ki Park  4 , Hyo-Won Jung  5
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Epimedium koreanum Nakai and its main constituent icariin suppress lipid accumulation during adipocyte differentiation of 3T3-L1 preadipocytes

Yunk-Yung Han et al. Chin J Nat Med. 2016 Sep.

Abstract

Obesity is associated with a number of metabolic abnormalities such as type 2 diabetes and has become a major health problem worldwide. In the present study, we investigated the effects of Epimedium koreanum Nakai (Herba Epimedii, HE) and its main constituent icariin on the adipocyte differentiation in 3T3-L1 preadipocytes. HE extract and icariin significantly reduced lipid accumulation and suppressed the expressions of PPARγ, C/EBPα, and SREBP-1c in 3T3-L1 adipocytes VSports手机版. They also inhibited fatty acid synthase (FAS), acyl-Co A synthase (ACS1), and perilipin. Moreover, HE extract and icariin markedly increased the phosphorylation of AMPK. These results indicated that HE extract and icariin can inhibit the adipocyte differentiation through downregulation of the adipogenic transcription factors, suggesting that HE containing icariin may be used as a potential therapeutic agent in the treatment and prevention of obesity. .

Keywords: 3T3-L1 cells; Epimedium koreanum Nakai; Herba Epimedii; Icariin; Obesity. V体育安卓版.

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