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Review
. 2016 Aug 23:7:271.
doi: 10.3389/fphar.2016.00271. eCollection 2016.

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition (V体育2025版)

Siti A Sulaiman  1 , Nurul-Syakima Ab Mutalib  1 , Rahman Jamal  1
Affiliations
Review

"V体育官网入口" miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

Siti A Sulaiman et al. Front Pharmacol. .

V体育安卓版 - Abstract

Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are single-stranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelial-to-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed. VSports手机版.

Keywords: EMT; metastasis; miR-200c; ovarian cancer; regulation. V体育安卓版.

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Figures

FIGURE 1
FIGURE 1
Functional regulation of metastasis cascade by miR-200c and its validated targets. Illustration of miR-200c functional role and its validated target in each of the metastases cascade. ECM, extracellular matrix.
See this image and copyright information in PMC

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